Investigation Of Risk Factors Related To Non-alcoholic Fatty Liver Disease In Hulunbeier

Objective:The study of risk factors associated with NAFLD in the Hulunbeier region will guide and deepen the population’s understanding of the disease and help to prevent NAFLD by correcting poor lifestyle habits,as well as identifying high-risk groups in the early stages of the disease and avoiding the associated risks to reduce the incidence of NAFLD in the region.Methods:Patients who attended the physical examination centers of four general hospitals in Hulunbeier area from November 2020 to December 2021 were selected as the subjects of this study.A total of 401 patients with NAFLD who had a complete physical examination report and complete abdominal ultrasound examination were selected using the convenience sampling method,and 400 normal patients who were physically examined at the same time were selected as the control group(non-NAFLD group).General data(basic information,living habits),height,weight,ALT,AST,GGT,TBIL,TG,TC,LDL-C,HDL-C,UA,FPG were collected from both groups.Data were entered using Excel,and the two groups of variables were analyzed using SPSS22 and logistic regression analysis was performed to collate the risk factors associated with the development of NAFLD based on the variables that were derived with differences.Results:1.A total of 401 patients with NAFLD were included in this study,and a total of400 patients in the control group,and the prevalence of NAFLD did not differ under each age and gender stratification(P > 0.05).2.A comparison of the general information of the two groups revealed that there was a statistically significant difference in smoking,lack of exercise,late nights,preference for meat,frying,snacking and milk tea(P<0.05),and there was no difference between the two groups in sedentary time and preference for diary products(P > 0.05).3.The levels of BMI,ALT,AST,GGT,TG,TC,LDL-C,UA,and FPG were higher in the NAFLD group than in the control group,and the levels of HDL-C were lower in the NAFLD group than in the control group,with statistically significant differences(P < 0.01),and there was no difference in age and TBIL levels between the NAFLD and control groups(P > 0.05).4.Grouped according to the diagnostic criteria of BMI,FPG and UA,the two groups were statistically different at different BMI,FPG and UA levels(P < 0.01).The proportion of NAFLD at BMI < 24 kg/m2,24 kg/m2 ≤ BMI < 28 kg/m2 and BMI ≥ 28kg/m2 was 20.6%,79.6% and 96.7% respectively.The proportion of NAFLD was higher for FPG≥6.1mmol/L(78.0%)than for FPG<6.1mmol/L(40.2%).The proportion of NAFLD was higher for UA≥420μmol/L(87.4%)than for UA ﹤ 420μmol/L(43.0%).Grouped according to the diagnostic criteria for dyslipidemia,there was a statistical difference between the two groups at different lipid levels(P < 0.01),and the proportion of NAFLD was higher at abnormal TC,TG,LDL-C and HDL-C than at normal TC,TG,LDL-C and HDL-C levels.5.The prevalence of combined overweight,obesity,abnormal lipid metabolism,hyperuricemia,and abnormal glucose metabolism was higher in the NAFLD group than in the control group,(P < 0.01).6.Multifactorial regression analysis showed BMI,TG,LDL-C,and UA were statistically different as risk factors for NAFLD(P < 0.01)and OR of 2.104,2.165,2.919,and 1.007,respectively.Conclusion:1.Elevated BMI,TG,LDL-C,and UA may be risk factors for NAFLD.2.Poor lifestyle habits in the Hulunbeier region,such as a preference for high fat diet,as well as the lack of exercise due to the low time of outdoors activities in relation to the region may be associated with the development of NAFLD in this region.