Mongolian Medicine For The Treatment Of Refractory Henoch Schnlein Purpura Nephritis’s Evaluation Of Clinical Curative Effect And Treatment Plan Optimization

Objective:1.To evaluate the efficacy of Mongolian medicine in the treatment of refractory henoch schonlein Purpura nephritis and optimize the treatment plan.2.Compare the curative effect of Mongolian medicine in treating refractory henoch schonlein Purpura nephritis with western medicine in treating refractory henoch schonlein Purpura nephritis,and confirm the better plan.Methods:In this study,30 patients with refractory henoch schonlein Purpura nephritis who met the diagnostic criteria and inclusion criteria and received Mongolian medicine treatment in the Affiliated Hospital of Inner Mongolia Minzu University from 2020.12 to2022.01 were selected as the treatment group.Treatment drugs: early fasting:Xinggegeqimandula,15 pills/time,Qingxuebaweisan sent to take;After lunch:Xuebaowan,15 pills/time,Guribenwulantang sent to take;After dinner: Eridun-wurile,15 pills/time,warm water to take;Evening before bed: Saligaridi,9 pills/time,warm water to take.The treatment lasted for 30 days,and the observation period was 2 cycles.30 patients with refractory henoch schonlein Purpura nephritis treated in the Affiliated Hospital of Inner Mongolia Minzu University from 2020.12 to 2022.01 were selected as the control group.Treatment drugs: vitamin C,calcium gluconate,compound glycyrrhizin,cimetidine and other symptomatic treatment.The treatment lasted for two weeks.The total clinical efficacy,improvement of main symptoms,improvement of urinary occult blood and urinary protein,quantitative improvement of urinary protein,evaluation and comparison of patients with Henoschonlein Purpura nephritis were compared between the two groups after treatment,and the influence of the two groups on blood routine,liver function,kidney function and other safety indicators were observed.Results:1.Comparison of total clinical efficacy between the two groups: complete response rate was 33.33%,partial response rate was 50%,and total response rate was 83.33% in the treatment group,while complete response rate was 16.67%,partial response rate was43.33%,and total response rate was 60% in the control group.There was statistical difference in efficacy between the two groups(P < 0.05).2.Comparison of the improvement of main symptoms between the two groups: there were significant differences between the two groups before and after treatment(P < 0.05).There was significant difference between the two groups in the improvement of skin purpura after treatment(P < 0.05).Other symptoms improved,but there was no significant difference(P > 0.05).3.Comparison of improvement of urine occult blood between the two groups: there were extremely significant differences between the two groups before and after treatment(P < 0.01).There was significant difference in the improvement of urine occult blood between the two groups after treatment(P < 0.05).4.Comparison of urine protein improvement between the two groups: there were extremely significant differences between the two groups before and after treatment(P <0.01).There was a significant difference in urine protein improvement between the two groups after treatment(P < 0.01).5.Comparison of quantitative improvement of urinary protein between the two groups:there were significant differences between the two groups before and after treatment(P <0.05).There was significant difference in quantitative improvement of urinary protein between the two groups after treatment(P < 0.05).6.After treatment,there were significant differences in somatic symptoms,skin purpura and hematuria.In terms of social and psychological aspects,there were significant differences in anxiety about the disease,enthusiasm for participating in social activities,aversion to purpura on the skin and recurrence,and significant differences in the improvement of daily work,aversion to purpura on the skin and recurrence after medical treatment.7.There were no significant differences in blood routine,liver function and renal function safety indexes between the two groups before and after treatment(P > 0.05).Conclusion:1.Mongolian medicine has good clinical effect in treating refractory allergic purpura nephritis2.Mongolian medicine is superior to western medicine in treating refractory allergic purpura nephritis.