| Objective: To analyze the clinical data of 1253 patients with primary bronchial lung cancer in Yanbian area,in order to preliminarily understand the clinical and pathological characteristics of Korean-Chinese Ethnic and Han Chinese patients with lung cancer,further strengthen the understanding of lung cancer,and provide scientific basis for the prevention,diagnosis and treatment of lung cancer.Methods: 1253 patients with primary bronchial lung cancer confirmed by pathology and admitted to our hospital from June 2017 to June 2021 were collected.The age,smoking history,body mass index,complications,pathological types and tumor markers of Korean-Chinese Ethnic and Han Chinese men and women with lung cancer patients were analyzed retrospectively.SPSS 26.0 software was used for statistical analysis,P<0.05 means a statistical difference.Results:1.The Han Chinese,compared with the young group,the constituent ratio of female elderly group was lower than that of male elderly group(P<0.05).In the Korean-Chinese Ethnic,compared with the young group and the middle-aged group,the constituent ratio of female elderly group was lower than that of male elderly group(P<0.05).Compared with the middle-aged group,the constituent ratio of KoreanChinese Ethnic male elderly group was higher than that of Han Chinese male elderly group(P<0.05).2.The proportion of Korean-Chinese Ethnic and Han Chinese female smokers was lower than that of male(P<0.05);The constituent ratio of Korean-Chinese Ethnic female smoking patients was lower than that of Han Chinese female(P<0.05).The constituent ratio of smoking in patients with adenocarcinoma was lower than that in patients with squamous cell carcinoma and small cell carcinoma(P<0.05).3.The constituent ratios of squamous cell carcinoma and adenocarcinoma in Han Chinese male patients were 33.6% and 41.6% respectively,those in Korean-Chinese Ethnic male patients were 40.0% and 38.1% respectively,those in Han Chinese female patients were 80.8% and those in Korean-Chinese Ethnic female patients were 94.1%.There was no significant difference between different pathological types and nationalities(P>0.05).Compared with adenocarcinoma,the constituent ratio of small cell carcinoma in Korean-Chinese Ethnic women were lower than that in Han Chinese women(P<0.05).The constituent ratio of squamous cell carcinoma,adenocarcinoma and small cell carcinoma was the highest in the elderly group(P<0.05).4.In Korean-Chinese Ethnic,the proportion of female patients with emphysema,chronic bronchitis and tuberculosis was lower than that of male patients(P<0.05);In the Han Chinese,the proportion of female patients with emphysema and chronic bronchitis was lower than that of male patients(P<0.05).The proportion of patients with adenocarcinoma complicated with emphysema,chronic bronchitis and tuberculosis was lower than that of patients with squamous cell carcinoma(P<0.05).The constituent ratio of KoreanChinese Ethnic male lung cancer patients with hypertension,diabetes and coronary heart disease was higher than that of Han Chinese men(P<0.05);The constituent ratio of Korean-Chinese Ethnic women lung cancer patients with diabetes is lower than that of Han Chinese women(P<0.05);The constituent ratio of Korean-Chinese Ethnic women lung cancer patients with hypertension,diabetes and cerebral infarction was lower than that of Korean-Chinese Ethnic male(P<0.05).Compared with the normal group,the proportion of overweight and obese lung cancer patients in Korean-Chinese Ethnic women were lower than that in Han Chinese women(P<0.05).The proportion of patients with adenocarcinoma complicated with dyslipidemia was lower than that of patients with squamous cell carcinoma(P<0.05).5.The positive rate of Neuron-specific enolase(NSE)and Progastrin-releasing peptide(Pro-GRP)in small cell carcinoma was higher than that in squamous cell carcinoma and adenocarcinoma,and the positive rate of Carbohydrate antigen 199(CA199)was higher than that in squamous cell carcinoma(P<0.05).The positive rates of Cytokeratin 19 fragment antigen21-1(Cyfra21‐1)and Squamous Cell Carcinoma Antigen(SCCA)in adenocarcinoma and small cell carcinoma were lower than those in squamous cell carcinoma(P<0.05).The positive rates of Carcinoembryonic antigen(CEA)and CA199 in adenocarcinoma were higher than those in squamous cell carcinoma and those in Carbohydrate antigen 153(CA153)were higher than those in squamous cell carcinoma and small cell carcinoma(P<0.05).Conclusion: 1.In Korean-Chinese Ethnic and Han Chinese,the number of patients with lung cancer increases with age.Smokers were more common in KoreanChinese Ethnic and Han Chinese male lung cancer patients,while Korean-Chinese Ethnic female smokers were less than Han Chinese female.2.The most common pathological types in male patients with lung cancer are adenocarcinoma and squamous cell carcinoma,and female patients are adenocarcinoma,there is no difference in nationalities.The quantities of small cell lung cancer in woman Korean-Chinese Ethnic are less than that in Han Chinese.3.Male Korean-Chinese Ethnic lung cancer patients with hypertension,diabetes and coronary heart disease were more than that of men Han Chinese.Female KoreanChinese Ethnic lung cancer patients with overweight,obesity and diabetes mellitus were less than that in Han Chinese women.Male Korean-Chinese Ethnic lung cancer patients with hypertension,diabetes and cerebral infarction were more than that in Korean-Chinese Ethnic women.Patients with squamous cell carcinoma are often complicated with emphysema,chronic bronchitis,pulmonary tuberculosis and dyslipidemia.4.The expressions of CEA,CA153 and CA199 were associated with adenocarcinoma;the expressions of Cyfra21-1 and SCCA were associated with squamous cell carcinoma;the expressions of NSE,Pro-GRP and CA199 were associated with small cell carcinoma. |
PDF Full Text Request