Study On Prescription Law Of Dietotherapy Medicated Diet In Traditional Chinese Medicine For Amnesia

Objective: By searching the literature,collecting and arranging the dietetic medicated diet recipes for preventing and curing amnesia.In this study,data mining of medicated diet prescription was conducted to explore the law of the syndrome differentiation of amnesia diet prescription and to construct the syndrome differentiation diet therapy plan.It provides the theoretical basis for the application of amnesia diet therapy and the standardization research of medicated diet.Methods: On the basis of theoretical discussion and literature review,according to inclusion criteria and exclusion criteria,the recipe of dietetic medicated diet for the treatment of amnesia in Chinese Medicated Diet Dictionary and Full Recording of Therapy Recipes of the Traditional Chinese Medicine was searched.The database of diet and medicinal diet prescription,raw material information and raw material of syndrome type were established respectively.By using Microsoft Excel 2016,Apriori algorithm in IBM SPSS Modeler 18.0and Ochiai algorithm in IBM SPSS Statistics 22,this paper analyzes the regularity of syndrome differentiation in prescription of dietotherapy medicated diet.Results:1、In this study,368 recipes of amnesia diet were collected,involving 270 kinds of raw materials,including 117 kinds of food raw materials,92 kinds of medicine raw materials,61 kinds of medicine and food dual-purpose raw materials,the use frequency of each raw material is 1519 times.The four nature of drugs were mainly warm(42.59%)and flat(38.83%),and the five flavours were mainly sweet(60.42%),bitter(13.03%)and pungent(12.52%).The combination of nature and flavour were mostly sweet and warm(62times)and sweet and flat(55 times).The five zang-organs meridians and collaterals were the core of the channel tropism,the spleen meridians(20.08%)and the kidney meridians(19.40%)were the majority.The lung meridians(14.14%),the liver meridians(13.26%)and the heart meridians(13.04%)were all distributed.The main ingredients of medicinal diet recipe were dishes(38.32%),drinks(26.09%)and congee(13.32%).The distribution of the syndrome types of dietetic medicated diet recipe were syndrome of deficiency of kidney essence(177),syndrome of deficiency of both heart and spleen(152),syndrome of disharmony between heart and kidney(30),syndrome of upward disturbance of phlegm-turbidity(8)and syndrome of qi stagnation and blood stasis(1).2、The raw materials,Association rules and cluster analysis were carried out for each type of medicated diet.The top 10 ingredients of syndrome of deficiency of kidney essence were medlar(46 times),walnut kernel(33 times),black sesame(20 times),rehmanniae radix(19 times),rehmanniae radix praeparata(15 times),chicken(14 times),ginger(14 times),honey(14 times),wine(14 times)and Japonica rice(12 times).In association rules,the drug pairs with strong association are Black sesame-Walnut,Tuckahoe-Rehmannia radix praeparata and etc.4 core combinations were extracted by cluster analysis.The top 10 ingredients of syndrome of deficiency of both heart and spleen were longan(43 times),Chinese date(32 times),lotus seed(26 times),japonica rice(21 times),chicken(18 times),ginseng(18 times),Chinese Wolfberry(16 times),Chinese Yam(16 times),angelica(14 times)and poria(14 times).In association rules,the drug pairs with strong association are Glutinous rice-Lotus seeds,Lilies-Lotus seeds and etc.5 core combinations were extracted by cluster analysis.The top 6 ingredients of syndrome of disharmony between heart and kidney were lotus seed(7 times),longan(6 times),rehmanniae radix(5 times),black bean(4 times),polygala tenuifolia(4 times),rock sugar(4 times),lilii(3 times),jujube(3 times),angelica(3times)and floating wheat(3 times).In association rules,the drug pairs with strong association are Black beans-Floating wheat,Medlar-Longan and etc.5 core combinations were extracted by cluster analysis.The data of syndrome of upward disturbance of phlegmturbidity and syndrome of qi stagnation and blood stasis prescription of medicated diet were less,accounting for 2.17% and 0.27% of total prescription frequency respectively,so there was no association rule and cluster analysis,only the frequency of commonly used raw materials was counted.The first 3 raw materials of medicinal diet in syndrome of upward disturbance of phlegm-turbidity were acorus tatarinowii,japonica rice and lili,and the raw materials of medicinal diet in syndrome of qi stagnation and blood stasis were albizzia and japonica rice.Conclusion: 1、The results of the analysis of the frequency of the commonly used raw materials and the properties of medicines in the prescription of amnesia diet and medicinal diet suggest that most cases of this disease are due to the deficiency of the five internal organs leading to the loss of brain medulla,or due to the obstruction of phlegm and blood stasis,but the essence of this disease is still deficiency,the medicine and food used are mainly warming and tonic.2、The law of each syndrome type medicated diet group: The prescription law of medicinal diet in syndrome of deficiency of kidney essence is mainly based on strengthening and nourishing marrow and essence,at the same time pay attention to invigorate spleen and replenish qi,and supplement congenital origin with acquired foundation.Replenishing blood for nourishing heart and benefiting qi for tranquillization are the main prescription of syndrome of deficiency of both heart and spleen.At the same time,appropriate to add strengthening spleen for regulating qi-flowing or resolving food stagnation medicine and food,to help transportation and transformation.On the basis of restoring normal coordination between heart and kidney,the syndrome of disharmony between heart and kidney was often compatible with invigorating spleen-stomach and replenishing qi,clearing asthenic fever and astringent medicine and food.Syndrome of upward disturbance of phlegm-turbidity and syndrome of qi stagnation and blood stasis take tonifying deficiency as the focal point,simultaneously match the medicine and food with the function of dissipating phlegm,dispelling stasis and activating qi.3、Based on the results of statistics,data mining and analysis of medication law,this study constructs a therapeutic scheme of Traditional Chinese Medicine syndrome differentiation for amnesia,and provides theoretical basis for clinical syndrome differentiation.