| Objective:To analyze the correlation of neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR)and other influencing factors in bone mineral density(BMD)of patients with type 2 diabetes mellitus(T2DM),so as to provide theoretical guidance and basis for clinical prediction of osteoporosis(OP).Methods:A total of 215 T2 DM patients were admitted to the hospital of Yanbian university in Ji Lin province from October 2018 to October 2021,including 137 females and 78 males,who were admitted to the endocrinology department of our hospital.Bone mineral density of the lumbar spine1-4(L1-L4),femoral neck and total hip was measured by Dual-energy X-ray absorptiometry(DEXA).When the bone mineral density T value of any site ≥-1.0 was normal bone mineral density,-2.5 < T value <-1.0 was considered reduced bone mineral density,and T value ≤-2.5 was considered osteoporosis.The subjects were divided into 73 cases in the osteoporosis group,78 cases in the reduced bone mineral density group and 64 cases in the normal bone mineral density group according to the T value.General data such as age,gender,ethnicity,height and weight were recorded separately,in addition to fasting blood glucose(FBG),glycosylated hemoglobin(HBA1c),liver function,kidney function,blood lipid indexes and peripheral blood routine indexes,and NLR,PLR were also collected.Statistical analysis was performed using SPSS26.0 software.Results:1.In patients with T2 DM,the differences in age and gender were statistically significant when comparing the three groups(P < 0.05),and in age the osteoporosis group was higher than the reduced BMD group and the normal BMD group,the reduced BMD group was higher than the normal BMD group.2.In patients with T2 DM,the Cys C of the three groups was statistically significant(P < 0.05),and the osteoporosis group was higher than the normal BMD group and the reduced BMD group.3.In patients with T2 DM,there were statistically significant differences in Hb,NEU,LYM,NLR and PLR among the three groups(P < 0.05).The osteoporotic group was lower than the reduced BMD group and the normal BMD group in Hb and LYM.The osteoporotic group was higher than the normal BMD group and the reduced BMD group was higher than the normal BMD group in NEU.The osteoporotic group was higher than the reduced BMD group and the normal BMD group in NLR.The osteoporotic group was higher than the normal BMD group in PLR.4.In patients with T2 DM,the UA of the osteoporosis group was statistically significant(P <0.05),with the male group being higher than the female group.5.In patients with T2 DM,L1-L4 and total hip BMD were negatively correlated with age(P <0.05)and positively correlated with Hb(P < 0.05).The femoral neck and total hip BMD were negatively correlated with Cys C and PLR(P < 0.05)and positively correlated with NEU(P < 0.05).The L1-L4,femoral neck and total hip BMD were negatively correlated with NLR(P < 0.05).6.In patients with T2 DM,NLR was positively correlated with FBG,NEU and PLR,but negatively correlated with LYM in the osteoporosis group(P < 0.05).PLR was negatively correlated with LYM,but positively correlated with PLT and NLR in the osteoporosis group(P <0.05).7.Logistic regression analysis showed that age,gender and NLR were risk factors for T2 DM combined with OP.8.The ROC curve was used to evaluate the clinical value of NLR and PLR in T2 DM combined with OP,and it was found that the best critical values of NLR and PLR were 1.869 and 109.756 respectively,and the areas under the curve was 0.733 and 0.653 respectively.The sensitivity of NLR was 56.2% and the specificity was 82.8%,while the sensitivity of PLR was 52.1% and the specificity was 79.7%.The area under the curve of the combined detection of the two was 0.733,with a sensitivity of 58.9% and specificity of 78.1% for predicting T2 DM combined with OP.Conclusion:1.In patients with T2 DM,the BMD of L1-L4,femoral neck and total hip were negatively correlated with NLR.The BMD of femoral neck and total hip was negatively correlated with Cys C and PLR.2.The risk of T2 DM combined with OP increases with age and NLR,with women being at greater risk of OP compared to men.3.NLR and PLR may have certain clinical predictive value for T2 DM combined with OP. |
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