Observation Of Curative Effect On The Treatment Of Macular Edema Secondary To Branch Retinal Vein Occlusion By The Method Of Liver Spleen Concordance

Objective: Based on the pathogenesis of Branch Retinal Vein Occlusion-Macular Edema(BRVO-ME)and the basic theory of traditional Chinese medicine,we investigated the clinical efficacy of the combination of anti-VEGF drugs with “Jia Wei Zhuan Yao Drink and Wu Ling San”in the treatment of BRVO-ME.The clinical efficacy of BRVO-ME with the combination of anti-VEGF drugs was investigated to provide an effective clinical basis for the treatment of BRVO-ME in Chinese medicine.Methods: Sixty patients(60 eyes)with Branch Retinal Vein Occlusion-Macular Edema who met the inclusion criteria were selected according to the randomization principle.They were divided into a test group and a control group,with 30 cases in each group.The experimental group received oral Chinese medicine soup plus flavor prolonged drink combined with Wu Ling San combined with intravitreal injection of razumab once;the control group received intravitreal injection of razumab once.The best corrected visual acuity(BCVA)and central macular thickness(CMT)of the macula were observed before,at week 4,week 6 and week 8 after treatment in the two groups,respectively,and statistical analysis was performed to evaluate the clinical effects.Results:(1)Comparison of related indexes:In BCVA and CMT,the BCVA and CMT in the test group improved significantly after 4w,6w and 8w of treatment compared with those before treatment,and the differences were statistically significant(P<0.05);in the control group,BCVA and CMT improved significantly after 4w and 6w of treatment compared with those before treatment,and the differences were statistically significant(P<0.05);in the control group,after 8w of treatment The difference was not statistically significant(P>0.05)in the control group after 8w of treatment,and BCVA and CMT were not statistically significant compared with those before treatment.In comparison between the two groups,the differences between the test group and the control group after 4w and 6w of treatment were not statistically significant(P>0.05);the effect of the test group was better than that of the control group after 8w of treatment,and the difference was statistically significant(P<0.05).For the total TCM evidence points,the test group was compared with pre-treatment at 4w,6w and 8w,respectively,and all yielded P<0.05,which was statistically significant;the control group improved on TCM evidence at 4w and 6w with P<0.05,which was statistically significant,but at 8w with P=0.209>0.05,which was not statistically significant.The comparison between the two groups,treatment 4w,6w and 8w,all yielded P<0.05,and the improvement of the TCM symptoms was significantly better in the test group.(2)Comparison of efficacy: after 4w of treatment,the total effective rate of the test group and the control group were 93.33% and 86.67%,respectively;after 6w of treatment,the total effective rate of the test group and the control group were 86.67% and 80%,respectively;the difference between the total effective rate of the two groups was not significant after4 w and 6w of treatment,with no statistical significance(P>0.05);after 8w of treatment,the total effective rate of the test group and the control group were 83.33% and 13.33%,respectively,with significant difference and statistical significance(P>0.05).After 8w of treatment,the total effective rate of the test group and the control group were 83.33% and 13.33%,respectively,with significant differences and statistical significance(P>0.05),and the treatment effect of the test group was better than that of the control group.Conclusion: The test group had significant efficacy in treating BRVO-ME,and the long-term treatment effect was better than the control group,which could better improve the TCM symptoms,improve visual acuity and delay the recurrence of macular edema.