Clinical Study Of Modified Si Er Wu He Decoction Combined With Fenmotong In The Treatment Of Decreased Ovarian Reserve Function In Kidney Essence Deficiency Syndrome

Objective : To observe and explore the clinical efficacy,safety and mechanism of sierwuhe decoction combined with Fenmoratong in the treatment of patients with renal sperm deficiency syndrome with decreased ovarian reserve function,and to provide a new theoretical basis for clinical treatment of this disease.Methods : A total of 90 patients with renal insufficiency syndrome and decreased ovarian reserve function were selected from the department of Gynecology of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from January 2020 to October 2021,who met the inclusion criteria.They were divided into the Traditional Chinese medicine group(n = 30),the Western medicine group(n = 30),and the Western medicine group(n = 30)according to the random number table method.The patients were treated with the addition and subtraction of Si255 He prescription,the addition and subtraction of Si255 He prescription combined with fenmortong and Fenmortong,respectively,for 3 consecutive menstrual cycles.By observing the three groups of patients before and after treatment of TCM syndrome integral,hormone levels,endometrial,ovarian volume,sinus follicle count changes,using SPSS 23.0 to analyze the data obtained,objective and scientific to evaluate the 425 joint Finn,please pass us side for treatment of kidney essence deficiency syndrome in patients with ovarian reserve function by clinical curative effect.Results: 1.Comparison of clinical comprehensive efficacy: After 3 menstrual cycles of treatment in the three groups,the comprehensive clinical efficacy of the Chinese and Western medicine group was 96.3%,the Chinese and Western medicine group was 83.3%,and the Western medicine group was 65.5%,with statistically significant differences(P < 0.05).According to the Chi-square test results,the Chinese and Western medicine group had the best therapeutic effect,followed by the Chinese medicine group.Again,the Western medicine group.2.Comparison of TCM syndrome total score: Intra-group comparison:comparison of TCM syndrome total score of patients in the three groups before and after treatment(P < 0.05),the differences were statistically significant,that is,the total SCORE of TCM syndrome of patients in the three groups decreased after treatment;Comparison between groups: the total score of TCM syndrome after treatment was compared,P < 0.001,the differences were statistically significant.Among them,the total score of TCM syndrome in the TCM group was less than that in the TCM group,and that in the TCM group was less than that in the Western medicine group.That is,after treatment,the total score of TCM syndrome in the TCM group decreased most obviously,followed by the TCM group,and finally the Western medicine group.3.Comparison of related indicators after 3 menstrual cycles:(1)After treatment,the FSH and LH levels of the three groups were compared within the group and between the groups,and the difference was statistically significant(P < 0.01).In other words,the Chinese and Western medicine group was superior to the Western medicine group and the Chinese medicine group in reducing serum hormone FSH and LH levels,and the Western medicine group was superior to the Chinese medicine group.In other words,after treatment,the efficacy of the Chinese and Western medicine group was the best,followed by the Western medicine group,and finally the Chinese medicine group.(2)Comparison of AMH level and endometrium within the three groups after treatment: P > 0.05 in the western medicine group and the Chinese medicine group,the difference was not statistically significant,while P < 0.05 in the Chinese and western medicine group,the difference was statistically significant,that is,the Chinese and western medicine group could regulate THE AMH level to some extent and make the endometrium thickened.Comparison between groups: after treatment,the levels of serum hormone AMH and endometrium in the three groups showed no statistical significance,P > 0.05.That is,there were no significant changes in AMH level and endometrial comparison among the three groups after treatment.(3)After treatment,there were no significant differences in bilateral ovarian sinus follicle count and bilateral ovarian volume between the three groups(P > 0.05),that is,there were no significant changes in bilateral ovarian sinus follicle count and bilateral ovarian volume in the three groups after treatment.Conclusions: 1.This study is based on the fact that essence is the source of human life.Essence belongs to yin and is stored in the kidney.When various factors lead to the consumption of kidney yin and essence,resulting in deficiency of heat and endogenous disturbance of essence and blood,kidney essence deficiency and blood stasis can occur.Therefore,kidney essence deficiency is the main pathogenesis of this disease.Therefore,the treatment should be based on tonifying kidney and filling essence,promoting blood circulation and dredging collaterals.2.Through the collation and analysis of the data in this study,it can be seen that the treatment of DOR patients with Sierwu Decoction combined with Fenmetoon can not only relieve symptoms,but also improve hormone levels.Its clinical efficacy is positive and its safety factor is high,which is worthy of clinical promotion and application.