Efficacy Observation Of Xiaoke Zengji Decoction In Intervening Type 2 Diabetes Combined With Sarcopenia

Objective: The clinical effect of Xiaoke Zengji decoction was observed,which intervened in type 2 diabetes mellitus combined with sarcopenia,aiming to provide new research ideas and reference plan for TCM treatment of type2 diabetes mellitus combined with sarcopenia in the future.Methods:Seventy patients with type 2 diabetes mellitus(T2DM)and sarcopenia(SP)were selected.which treated in the department of endocrinology,Qingdao Hospital of Traditional Chinese Medicine.35 patients were randomly divided into the treatment group,and the others were randomly divided into the control group.The control group gave basic intervention measures,including nutritional support and physical exercise,and the treatment group added Xiaoke Zengji decoction on the basis of the control group’s intervention measures,1 dose per day with 150 ml of boiled water half an hour before the morning and evening.The observation cycle of both groups was 12 weeks,which observed before and after treatment in changing in points of TCM symptoms,BMI,fasting blood glucose(FPG),glycosylated hemoglobin(Hb A1c),fasting insulin(FINS),insulin resistance index(HOMA-IR)and Pancreatic cell function(HOMA-β),grip force,pace,and the score of daily life(ADL score).The obtained data were included in the database for statistical analysis to observe the clinical effect of Xiaoke Zengji decoction.Results:1.A total of 70 patients were included in this study.After statistical treatment,there was no significant difference in the gender,disease course and age between the two groups before treatment((49)(27)0.05),the two groups were comparable.2.After treatment,BMI,FPG,Hb A1 c,HOMA-IR,and HOMA-β improved with statistically significant differences than before((49)<0.01).Comparison between the two groups: the treatment group was better than the control in decreasing FPG,HOMA-IR and improving HOMA-β((49)<0.01);after treatment,there was no significant difference in BMI between the two groups((49)> 0.05)as well as Hb A1 c.((49)> 0.05).3.After treatment,grip strength,step speed,and ADL scores improved significantly((49)<0.01),the calf circumference also improved in both groups((49)<0.05).Comparison between the two groups: The treatment group was better than the control in enhancing grip strength,improving step speed and improving daily activities((49)<0.01),but there was no significant difference in the improvement of calf circumference between the two groups((49)> 0.05).4.After treatment,the symptom scores of TCM improved significantly between the two groups compared with before treatment((49)(27)0.01);the effective rate of TCM symptoms was 82.9% in treatment group,and the control group was 48.6%.The treatment group was significantly better than the control group in improving clinical symptoms and efficacy((49)(27)0.01).5.During the treatment,neither group had any obvious adverse effects,and safety indicators such as liver and kidney function were within the normal range.Conclusion: The results showed that the effect of Xiaoke Zengji decoction was better than simple basic dietary intervention and resistance training for type 2 diabetes patients with sarcopenia.Studies confirmed that the Xiaoke Zengji decoction can reduce blood sugar,insulin resistance and improve the function of pancreatic cell effectively.The TCM decotion could also enhance patient muscle strength effectively,improve muscle function,reduce symptoms and improve clinical effect significantly,which safety was reliable.It was an effective prescription to improve the syndrome with spleen and stomach deficiency,kidney deficiency and blood stasis which was type 2 diabetes combined with sarcopenia patients.