Clinical Study Of Chaihu Wenqing Decoction In The Treatment Of Middle-aged Chronic Insomnia With Chills And Heat

Objective: To observe the clinical efficacy of Chaihu Wenqing Decoction in the treatment of middle-aged chronic insomnia with cold and heat mixture,to clarify its therapeutic effect and safety,and to further explore the mechanism of action of Chaihu Wenqing Decoction on this syndrome type insomnia.Methods: Taking middle-aged patients with chronic insomnia(cold and heat mixed type)as the research object,66 patients with inclusion and exclusion criteria were selected and randomly divided into treatment group and control group,33 patients in each group.The treatment group was given self-drafted prescription "Chaihu Wenqing Yin" oral treatment,and the control group was given alprazolam tablet oral treatment.The treatment course lasted for 4weeks.During this period,the changes of TCM symptoms and signs and PSQI scores before and after treatment in 2 groups were observed and statistically analyzed.Results: A total of 63 patients successfully completed the study,2 cases in the control group were eliminated,1 case in the treatment group was dropped.After statistical analysis,there was no significant difference between the treatment group and the control group in general information including age,gender,PSQI score and TCM syndrome score before treatment(P > 0.05).After four weeks of treatment,the total effective rate of TCM symptom score was87.5% in the treatment group and 70.9% in the control group.The curative effect of the treatment group was significantly better than that of the control group(P < 0.05).The PSQI scores of the two groups after treatment were better than before,and the data of the treatment group was better than the control group after treatment(P < 0.05),the differences were statistically significant.There were no obvious adverse reactions in the two groups,and there was no statistical difference in safety indicators.Conclusion: through the study found that radix bupleuri Wen Qing drinks in the treatment of fever type middle-aged mixed chronic insomnia,can significantly improve sleep at night,relieve daytime function damage,and clinical symptoms of fever and pathogenesis of mixed cause has obviously improved,its curative effect is superior to the application of alprazolam,found no obvious side effects,suitable for promotion.