Based On Radiographic Performance,the Influencing Factors Of Brain Injury In Preterm Infants Were Analyzed

Objective:Based on the imaging results,the incidence of brain injury in preterm infants and the analysis of influencing factors are analyzed,which provides a reliable theoretical basis for formulating their early intervention strategies and measures.Research Objects and Methods:In this study,preterm infants(gestational age<37 weeks)who underwent imaging from July 1,2020 to December 31,2021 at the Obstetric Department of the Affiliated Hospital of Yan’an University and were transferred to the Neonatology Department for>7 days,were divided into two groups according to the B Super MRI results:the group without brain injury and the brain injury group,and the brain injury group could be divided into hemorrhagic brain injury group and non-hemorrhagic brain injury group.Collect data,including perinatal risk factors,birth and hospitalization data of preterm infants,etc.,use SPSS 22.0 statistical software for data analysis,use mean ± standard deviation(χ±s)for measurement data,use cases(n)and percentage(%)of counting data,use χ2 test and Fisher accuracy test for intergroup comparison,and use univariate and multivariate logistic regression analysis for the analysis of influencing factors of brain injury(BIPI)in preterm infants.In order to avoid the fact that the real and valid variables may be underestimated or obscured,we set the inclusion criteria for the results of one-factor analysis to P<0.1,and the difference between P<0.05 of multi-factor analysis results is statistically significant.Outcome:1.General data:A total of 239 hospitalized preterm infants were included in this study,including 142 males(59.41%),97 females(40.59%),34.29 ± 2.13 weeks(range:27+4～36+6 weeks),average birth weight 2162.71 ±556.12g(range:950～3780g),3 cases at<28 weeks(1.26%),36 cases at 28-<32 weeks(15.06%),32-<34 weeks(51 cases(21.34%),149 cases at34～<37 weeks(62.34%).The median length of hospital stay was 11 days(range:9 to 16 days).2.Brain injury:Among the 239 children with gestational age<37 weeks,a total of 62 cases(25.94%)of brain injuries were found,including 38 cases of hemorrhagic brain injury(prevalence of 15.90%),accounting for 61.29%of all preterm infants with brain injury,24 cases of non-hemorrhagic brain injury(prevalence of 10.04%),accounting for 38.71%of all preterm infants with brain injury.3.Hemorrhagic brain injury:According to the results of univariate analysis,sex,gestational age,birth weight,mode of delivery,whether there is first birth,preterm labor,intrauterine distress,prenatal use of hormones,asphyxia,umbilical cord around the neck,mechanical ventilation,apnea,NRDS,anemia,sepsis and coagulation function abnormalities,abnormal WBC count and hemorrhagic occurrence are statistically significant(P<0.1).Multivariate logistic regression analysis showed that gestational age,mode of delivery,whether antenatal hormones were used,and whether umbilical cord circumvention,asphyxia,sepsis,apnea and the occurrence of hemorrhagic brain injury were statistically significant(P<0.05).4.Non-hemorrhagic brain injury:According to the results of univariate analysis,gestational age,birth weight,maternal pregnancy anemia,hypertension,amniotic fluid,neonatal asphyxia,apnea,neonatal respiratory distress syndrome(NRDS),neonatal necrotizing enterocolitis NEC,anemia and use of PS in children,Mechanical ventilation was associated with non-hemorrhagic occurrence,and the difference was statistically significant(P<0.1).Multivariate logistic regression analysis showed that there were statistically significant differences in gestational age,maternal hypertension,amniotic fluid abnormalities,use of PS,mechanical ventilation,NEC and the occurrence of nonhemorrhagic BIPI(P<0.05).Conclusion:1.In BIPI,PVH-IVH was the most hemorrhagic(52.63%),while cerebral edema and PVL were the main non-hemorrhagic ones(54.17%,29.17%);2.In hemorrhagic brain injury,it showed that older gestational age and prenatal use of hormones and caesarean section were their protective factors,while umbilical cord circumference,asphyxia,apnea,sepsis,preterm labor,and intrauterine distress were their risk factors,and the differences were statistically significant(P<0.05);3.In non-hemorrhagic brain injury,PS is used as protective factors for older gestational age and after birth,while maternal hypertension,amniotic fluid abnormalities,mechanical ventilation,and NEC are their risk factors(P<0.05).