The Clinical Study On Correlation With Cough After Lobectomy And Postoperative Changes In Pulmonary Arterial Pressure

Objective: To explore the correlation between the degree of cough and the change of pulmonary artery systolic pressure in patients with Cough after Pulmonary Resection(CAP)after lobectomy,and to provide a new strategy for clinical intervention in cough after lobectomy,so as to improve the symptoms of postoperative cough and provide patients with a better experience of rapid recovery after thoracic surgery.Methods: A prospective study was conducted to analyze 42 patients with persistent cough after thoracoscopic lobectomy admitted to the Department of Thoracic and Cardiovascular Surgery in the Affiliated Hospital of Chengdu University from July2020 to August 2021.The basic clinical data,cough score(VAS and LCQ-MC)and echocardiography of the patients were followed up and collected,and the change of cough and the collected data in patients with postoperative cough were statistically analyzed to study the correlation between the occurrence of cough after lobectomy and changes in PASP.Results: 1.The cough scores(including the score of VAS and LCQ-MC)and echocardiographic measurements(including TRVmax and PASP)in patients with CAP after lobectomy were measured at four different times(including before surgery,3 days after surgery,1 month after surgery and 3 months after surgery).The values of the points were all different,and the differences were all statistically significant(P<0.05).2.The changes of PASP and cough degree of patients with CAP after lobectomy were changed over time.For the value of PASP in CAP patients,the value at 3 days after operation > 1 month after operation > 3 months after operation > before operation(P< 0.05);for the LCQ-MC score of CAP patients,the score at before operation > 3months after operation > 1 month after operation > 3 days after operation(P < 0.05).3.The PASP in the group with severe cough(LCQ-MC total score ≤13.41)was higher than that in the mild(LCQ-MC total score(29)13.41)group(34.09±6.63 mm Hg vs28.75±4.85 mm Hg)in three days after surgery,and the difference was statistically significant(P<0.05).There were no statistically significant differences in PASP between groups with different cough levels at the two time points of 1 month and 3months after surgery.4.The correlation tests of the total score of LCQ-MC(13.42±2.29),the PASP(31.55±6.38 mm Hg)and the difference of PASP on the 3rd day after surgery,the P were both <0.05,indicating that their correlations were statistically significant,and the correlation coefficient the r values were < 0,indicating that the two were negatively correlated.The correlation tests of LCQ-MC total score,PASP and pulmonary artery systolic pressure difference before operation,1 month and 3 months after operation were all P >0.05,and their correlation were not statistically significant.Conclusion: 1.The changes of cough degree and PASP with postoperative time in CAP patients after lobectomy are similar;2.The cough severity in patients with CAP after lobotomy 3 days is moderately positively correlated with PASP;3.Elevated PASP after lung surgery may be one of the important factors affecting the degree of cough in patients with CAP.