| ObjectiveTo observe the clinical efficacy and safety of knife-edge-needle intervention in the treatment of stroke-related headache of blood stasis type,and to provide a new therapeutic idea for stroke-related headache of blood stasis type.MethodsAccording to the inclusion criteria,60 patients with stroke-related headache were selected,and the patients were divided into the edge-needle treatment group and the CELECOXIB control group with 30 cases each,the treatment group was treated by knife-edge needle,the treatment group was treated by Western medicine,the treatment group was treated by Celecoxib,the control group was treated by Western medicine,the treatment group was treated by CELECOXIB.The scores of TCM syndromes,VAS scores,frequency of headache and headache scores were recorded before treatment and2 and 4 weeks after treatment in the edge-needle Group and Celecoxib Control Group,and before and after treatment HIT-6 score,Hama,Hamd,the effectiveness of treatment evaluation.Blood Routine(WBC,RBC,Plt),liver function test(ALT,AST),renal function test(Bun,CR)were collected before and after treatment in edge-needle treatment group and CELECOXIB control group.SPSS20.0 statistical software was used for statistical analysis of all data results.Results1.Before treatment,the general data,scores of TCM syndromes,visual analogue scale(VAS),frequency of headache and headache scores of the edge-needle treatment group and Celecoxib Control Group,there was no significant difference in HIT-6 score,Hamilton Anxiety Rating Scale score and Hamilton depression scale(P> 0.05)between the two groups.2.Analysis of clinical therapeutic effect of TCM SYNDROME INTEGRAL: After treatment,the cure rate,apparent efficiency and effective rate of edge-needle treatment group were higher than Celecoxib Control Group.3.Visual analogue scale(VAS)of pain: After treatment,the efficiency of edgeacupuncture Group and CELECOXIB control group was equal,but the clinical cure rate and significant efficiency of edge-acupuncture group were significantly higher than Celecoxib Control Group.4.Scores of TCM syndromes of headache: After treatment,scores of TCM syndromes of both knife-needle Treatment Group and Celecoxib control group decreased(P < 0.05),compared with Celecoxib Control Group,the edge-needling Treatment Group has obvious advantage in reducing the integral of TCM Syndrome.5.Visual analogue scale(VAS)of pain: After treatment,the VAS scores of edge acupuncture group and CELECOXIB control group were decreased(P < 0.05).After 2 weeks of treatment,the treatment group was superior to the CELECOXIB control group in reducing the VAS score.After 4 weeks of treatment,the VAS scores of the two groups were reduced equally.6.HIT-6 score: After treatment,the HIT-6 score decreased in both groups(P < 0.05),but the decrease in Celecoxib control group was worse than that in edge-needle Treatment Group.7.Frequency of headache: After treatment,the frequency of headache decreased in both knife-edge Acupuncture Group and Celecoxib Control Group(P < 0.05).After2 and 4 weeks,the frequency of headache in knife-edge acupuncture group was better than that in Celecoxib control group.8.Headache Score: After treatment,the score of headache in edge-acupuncture Group and CELECOXIB control group was improved(P < 0.05).After 2 weeks of treatment,the scores of headache in both groups were the same.After 4 weeks of treatment,the improvement of edge-needling group was better than that of CELECOXIB control group.9.Hamilton Anxiety Rating Scale: After treatment,anxiety was improved in both groups(P < 0.05),but the edge acupuncture group was better than Celecoxib Control Group.10.Hamilton Depression scale: After treatment,the depressive state of both groups was improved(P < 0.05),but the edge-needle treatment group was significantly better than CELECOXIB control group.11.Safety Assessment: Before and after treatment,blood routine(white blood cells,red blood cells,platelets),liver function test(Alanine transaminase,aspartate transaminase),renal function test(urea nitrogen,creatinine)were in the normal range.There was no significant difference in the incidence of adverse reactions between the two groups,which showed that both the edge-needle Treatment Group and the Celecoxib Control Group had good safety.Conclusions1.Both knife-edge Acupuncture Treatment Group and CELECOXIB control group have good clinical efficacy and safety in the treatment of stroke-related headache.2.Compared with Celecoxib Group,knife-edged Needle Group had advantage in improving TCM Syndrome score,frequency of headache attack,influence of headache on daily life and anxiety and depression. |