Effect Of Nourishing Qi And Blood Method On Accommodative Function Of Mild-to-moderate Myopia Patients With Qi And Blood Deficiency

Objective:To observe the effect of nourishing qi and blood method on traditional Chinese medicine(TCM)state and accommodative function of patients with qi and blood deficiency myopia by taking Bazhenfuming decoction orally.To explore the possible mechanism of nourishing qi and blood method in the treatment of mild to moderate myopia with qi and blood deficiency,so as to provide new clinical ideas for the prevention and control of juvenile myopia.Methods:76 cases(152 eyes)were diagnosed as mild or moderate myopia and identified as "sickened: deficiency of Qi and blood of water wheel" by TCM state identification.They were randomly divided into treatment group and control group,with 38 cases(76 eyes)in each group.Finally,36 cases(72 eyes)in the treatment group and 38 cases(76 eyes)in the control group were completed.The treatment group wore glasses combined with Bazhenfuming Decoction for oral administration for four weeks.The control group only wore frame glasses to correct refractive error.Analyze the relationship between TCM syndrome element score and naked eye visual acuity(NV),diopter,accommodative function and visual fatigue score before treatment.The differences of naked visual(NV),refractive degree,TCM syndromes score,accommodative function and visual fatigue score were compared before and after treatment.Results:1.Correlation analysis: before treatment,the correlation coefficients between Qi deficiency syndrome element score,blood deficiency syndrome element score and NV(Log MAR)were r=0.502,0.706,and the correlation coefficients with diopter were r=-0.696,-0.559;Correlation coefficient with amplitude of accommodation(AMP)r=-0.680,-0.580;Correlation coefficient with binocular accommodative facility(AF)r=-0.730,-0.521;Correlation coefficient with positive relative accommodation(PRA)r=0.510,0.583;Correlation coefficient with accommodative response(AR)r=0.510,0.534;Correlation coefficient with visual fatigue score r=0.913,0.724.All P < 0.05.2.The NV(Log MAR)of the treatment group before and after treatment were(0.60(0.40,0.98)),(0.50(0.30,0.70)),and the difference was statistically significant(P < 0.05);There was no significant difference in diopter before and after treatment in the treatment group(P > 0.05).There was no significant difference in NV(Log MAR)and diopter in the control group before and after treatment(P > 0.05).There was a significant difference in NV between the two groups after treatment(P < 0.05),but there was no significant difference in diopter between the two groups(P > 0.05).3.Before and after treatment,the binocular AF in the treatment group were(6.75(3.13,9.00))cpm / min and 12.00(9.25,13.00))cpm / min;The PRA of the treatment group before and after treatment were(-2.26 ± 0.78)D and(-2.70 ± 0.43)D;Before and after treatment,the binocular AF in the control group were(7.00(5.80,10.25))cpm/min and(9.00(7.00,11.00))cpm / min;The difference was statistically significant(P < 0.05).There was no significant difference in binocular AMP,negative relative accommodation(NRA)and AR in the treatment group before and after treatment(P > 0.05).There was no significant difference in binocular AMP,PRA,NRA and AR in the control group before and after treatment(P >0.05).After treatment,there was significant difference in binocular AF and PRA between the two groups(P < 0.05),but there was no significant difference in binocular AMP,NRA and AR between the two groups(P > 0.05).4.The qi deficiency syndrome element score and blood deficiency syndrome element score in the treatment group were(136.93 ± 23.99)points,(134.44 ± 24.00)points before treatment and(94.32 ± 27.39)points,(109.27 ± 20.73)points after treatment.The differences were statistically significant(P < 0.05).There was no significant difference in qi deficiency syndrome element score and blood deficiency syndrome element score in the control group before and after treatment(P > 0.05).After treatment,there was a significant difference in qi deficiency syndrome element score and blood deficiency syndrome element score between the two groups(P < 0.05).5.The scores of visual fatigue in the treatment group before and after treatment were(8.89 ± 3.64)points and(5.53 ± 3.17)points,with a significant difference(P < 0.05).The scores of visual fatigue in the control group before and after treatment were(8.71 ± 2.29)points and(7.39 ± 2.38)points,with significant differences(P < 0.05).There was a significant difference in visual fatigue score between the two groups after treatment(P <0.05).Conclusions:1.the syndrome element score of qi deficiency and blood deficiency was positively correlated with NV(Log MAR),diopter(D),binocular AMP(D),AR(D)and visual fatigue score,and negatively correlated with binocular AF(cpm/ min)and PRA(D).That is,with the increase of qi deficiency and blood deficiency syndrome element score,the naked eye visual acuity and accommodative function decreased and the visual fatigue score increased.2.Nourishing qi and blood method can effectively reduce the qi deficiency and blood deficiency syndrome element score of mild-to-moderate myopia patients with qi and blood deficiency,and improve the qi and blood deficiency of the whole body and eyes.3.Nourishing qi and blood method can effectively improve NV,binocular AF and PRA,and improve the accommodative function of mild-to-moderate myopia patients with qi and blood deficiency.