Analysis Of Professor Hong Minli Treating Chronic Cough From Phlegm And Retained Fluid Based On The Traditional Chinese Medicine Inheritance Support System

Objective: To analyse cases of Professor Hong Minli in treating of chronic cough from phlegm and retained fluid,summarize medical empirical research based on the Traditional Chinese Medicine Inheritance Support System V2.5(TCMISS).In order to further deepen the understanding of their relationship,improve the clinical level.Methods: The cases of chronic cough patients treated by Professor Hong Minli in the Department of Pulmonary Diseases,Zhangzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine from January 2020 to December 2021 were collected and selected into this study according to the inclusion criteria and exclusion criteria.After the case data standardized,the case data were entered the "Traditional Chinese Medicine Inheritance Support System V2.5(TCMISS)",and established the "Medical record Database" and "prescription Database".The common syndromes and high-frequency prescriptions were counted and analyzed,syndrome differentiation and prescription thinking were extracted,the prescriptions were analyzed and clustered,so as to found out the potential core combination and formed new prescriptions,and then summarized Professor Hong Minli’s clinical experience in treating chronic cough from phlegm and retained fluid.Results:1.General data analysis: A total of 71 patients and 266 visits were included in this study,including 35 men and 36 women.The proportion of female patients was slightly higher than that of men.In the age of onset,the majority were 40-49 years old.2.Syndromes analysis: In the syndrome analysis of 266 visits,cough was the main symptom.The characteristics of cough including pharyngeal itching cough,night cough,cold cough,irritant cough,throat-clearing cough and so on.Other syndromes were whitish and thin sputum,sensation of throat blockage,thirst,chest tightness and short breath,sallow complexion,floating whitish complexion,etc.Chronic cough patients in this topic,except for the normal tongue,other tongues were bulgy tongue and tooth-marked tongue,the tongue color was mostly light red tongue,light whitish tongue and dim tongue,and the tongue fur was mainly thin white tongue fur,thick white tongue fur and slippery tongue fur.The pulse was mostly composed of slippery pulse and string pulse.3.Recipe analysis: This study involved 26 commonly used prescriptions,such as Chaipu Tang,Xiao Qinglong Tang,Guizhi Tang,Xiao Chaihu Tang,Yupingfeng San,Liujunzi Tang Banxia Houpo Tang,etc.A total of 106 traditional Chinese medicines were used,exclusion of licorice,the top 10 high-frequency drugs with a frequency greater than 100 times were Pinellia,Poria,Ginger,Radix Bupleuri,Radix Scutellariae,Cassia twig,Rhizoma Atractylodis Macrocephalae,Radix Paeoniae,Radix Codonopsis and Fructus Ziziphi Jujubae.The four natures of these medicine were mainly warm,the five flavors were mainly pungent and sweet,and the main meridians tropism were lung-meridian,spleen-meridian and stomach-meridian.4.Analysis of prescription drug use rules: Based on the analysis of association rules,there were 26 groups in which the probability of simultaneous occurrence of two drug combinations more than 30%,and the confidence of 14 association rules was more than 0.85.The commonly used drug combinations were Pinellia-Poria,Ginger-Pinellia,Radix Scutellariae-Radix Bupleuri,Rhizoma Atractylodis Macrocephalae-Poria,Cassia twig-Radix Paeoniae,involving 11 core drugs,which could constitute commonly used prescriptions.Using the entropy hierarchical clustering algorithm,14 pairs of core prescriptions and 7groups of potential new prescriptions were extracted.Conclusion:Professor Hong Minli believes that "phlegm and retained fluid,combine with other pathogenic factors" is the main pathogenesis of chronic cough patients.Professor Hong Minli focus on the collection of four diagnosis information,especially inspection(complexion,body,tongue,as well as color,nature and quality of sputum)and inquiry(cough characteristics),to differentiation of phlegm and retained fluid.Based on data mining technology,summarize professor Hong Minli take "warming yang for resolving retained fluid" as the main principle,using dispersing the lung and expelling cold,reinforcing the spleen and resolving retained fluid,warming and tonifying kidney-yang,meanwhile treating shaoyang disease by mediation,smoothing triple energizer and regulating qi,etc.Professor Hong Minli is good at using of classical prescription,the medication characteristics manifested warming and clearing,descending and opening with drugs bitter and pungent in combination.In the later stage,Professor Hong Minli mainly regulate and tonify the middle energizer,strengthen the spleen and stomach,makes phlegm and retained fluid come to nothing.