Clinical Observation Of Tongning Decoction In The Treatment Of Acute Gouty Arthritis With Damp-heat And Stasis Syndrome

Objective:To observe and evaluate the clinical effects and safety of Tongning Decoction in treating damp-heat and stasis syndrome of acute gouty arthritis.Methods:In the study,62 patients with damp-heat and stasis syndrome of acute gouty arthritis who met the inclusion criteria were divided into the control group(31 cases)and the observation group(31cases)by the random number table method.Before the treatment,patients in both groups received gout education to adjust their lifestyle and diet structure.The control group was given Etoricoxib Tablets(120mg,once a day).On the basis of the control group,the observation group was treated with "Tongning Decoction"(1 dose per day,about 200 ml twice in the morning and evening).The observation period of both groups was 1 week.By using SPSS 22.0 statistical software,we compared the changes of two groups of patients before and after treatment of the TCM syndrome total scores,the single score of TCM syndrome,VAS scores,the index of joint swelling and pain,and security indicators to evaluate the efficacy and safety of Tongning Decoction.Results:1.Comparison of general date and the baseline of both groups: There were no significant statistical differences in general data(age,gender,disease course),the TCM syndrome total scores,the single score of TCM syndrome,VAS scores,the index of joint swelling and pain,the levels of ESR,CRP and SUA(P>0.05),indicating that both groups were comparable.2.After 1 week of treatment,the total effective rate of the control group was 80.00%,and the total effective rate of the observation group was 93.55%,and there was a significant difference between both groups(P<0.05).The curative effect of TCM syndrome in the observation group was better than that in the control group.3.There were statistically significant differences in the TCM syndrome total scores before and after the treatment within each group(P<0.05),and the two treatment plans of both groups could improve the TCM syndromes.After the treatment,the TCM syndrome total scores in the observation group were significantly lower than that in the control group(P<0.05).The observation group was better than the control group in the improvement of joint pain,joint redness,joint fever,body heat,body drowsiness,joint tingling and pain at a certain place,urine short yellow,and other TCM syndrome(P<0.05).4.There were statistically significant differences in VAS scores before and after the treatment within each group(P<0.05),and the two treatment plans of both groups could improve joint pain.After the treatment,VAS scores in the observation group were significantly lower than that in the control group(P<0.05).After the treatment,the index of joint swelling and pain in the observation group was better than that in the control group,with statistical significance(P<0.05).Compared with the control group,the observation group had better improvement in joint swelling and pain symptoms.5.There were statistically significant differences in the levels of ESR,CRP,and SUA between both groups before and after treatment(P<0.05),and the two treatment plans of both groups could reduce the levels of ESR,CRP,and SUA.After the treatment,the levels of ESR,CRP,and SUA in the observation group were significantly lower than that in the control group,with statistical significance(P<0.05).The observation group was superior to the control group in reducing the levels of ESR,CRP,and SUA.6.Security aspect: During the treatment,there were no nausea,stomachache,diarrhea,other gastrointestinal symptoms,dizziness,palpitation,rash,and other adverse reactions,and no obvious abnormalities in blood routine,urine routine,fecal routine,and occult blood and electrocardiogram.There were no significant differences in the levels of AST,ALT,Scr,and BUN between the 2groups before and after treatment(P>0.05),nor between the 2 groups after the treatment(P>0.05).The two treatment plans of both groups had good safety.Conclusion:1.The clinical efficacy of Tongning Decoction combined with Etoricoxib Tablets in the treatment of damp-heat and stasis syndrome of acute gouty arthritis was better than Etoricoxib Tablets.2.Tongning Decoction combined with Etoricoxib Tablets could effectively improve the TCM syndromes,the symptoms of joint swelling and pain in the patients with damp-heat and stasis syndrome of acute gouty arthritis,with good safety.