Clinical Observation Of Phytic Acid Ketone And HIFU In The Treatment Of High-risk HPV Infection With Or Without CINI

Objective;This project is to observe the clinical efficacy of Phytic acid ketone and focused ultrasound in the treatment of high-risk HPV infection with or without CINI,explore the therapeutic effect of Phytic acid ketone and focused ultrasound respectively and the effect of combined application in the treatment of cervical lesions,explore its feasibility and safety,and provide scientific theoretical basis for the promotion of this treatment mode.Methods;the research object were diagnosed with high-risk HPV infection or high-risk type HPV infection with CINI lesions from jiangxi province maternity and child care hospital wards of department of gynaecology,Haifu center and gynecological clinic in during October 2020 to March 2021.patients who meet the inclusion criteria and have been excluded,randomly divided into four groups;control group(interferon treatment),drug group(Phytic acid ketone treatment),ultrasound group(focused ultrasound treatment),combined group(focused ultrasound plus phytateone treatment),30 patients were selected from each group.The effects of Phytic acid ketone and focused ultrasound on HPV negative conversion rate,CIN reversal rate and anxiety score before and after treatment were observed.Results;We collected 127 patients,of which 120 were effective,and finally made statistical analysis.(1)Comparison of HPV negative conversion rate;3 months after treatment,the negative conversion rate of the 4 groups was;combined group(73.3%)> ultrasound group(60%)> drug group(23.3%)> control group(20%).Pin-pide comparison between the two groups(corrected by Bonferroni method)showed that the ultrasound group and combined group had statistical significance compared with the control group(P<0.008).The negative conversion rate in the drug group was higher than that in the control group,but the difference was not statistically significant(P>0.008).The negative conversion rate of treatment after 6 months showed that combined group(96.3%)> drug group(70%)> ultrasound group(66.7%)> control group(23.3%).There was significant difference between the experimental group and the control group(P<0.008),there was no significant statistical difference between the drug group and the ultrasound group,However,the treatment effect was different from that of March,the negative conversion rate of drug treatment increased significantly,and there were statistical differences between the combined group and the other three groups.(2)The rate of CIN reverse comparison;Reverse rate for 3 months after treatment group;combined group(73.3%)> ultrasonic group(64.3%)> drug group(28.6%)> the control group(23.3%),pair-up comparison(corrected by Bonferroni method)showed that there was statistical statistical difference between the combined group and control group as well the control group and the ultrasound group(P<0.008),while there was no significant difference between the drug group and the control group.The reversal rate of CINI at 6 months after treatment was as follows;combination group(96,7%)> ultrasound group(71.4%)> drug group(67.9%)>control group(30%)pairwise comparison;the comparison between all treatment groups and control group was statistically significant(P<0.008),and combination group was better than single treatment plan(P<0.008).(3)Comparison of Hamilton anxiety score;scores at 3 months and 6months after treatment were compared with those at treatment Intra-group comparison before treatment showed statistical difference(P<0.01).This indicates that the use of drugs and physical therapy for patients infected with the virus can relieve their anxiety state to a certain extent.(4)Hamilton Anxiety score was compared among the four groups 3 months after treatment(Kruskal-wallis test)showed that there was statistically significant difference between the four groups(P<0.01).After 6 months,there were significant statistically differences between the 4 groups(P<0.01),and the effect of the combined treatment group on improving anxiety was significantly higher than that of the other treatment groups.Conclusion;Phytic acid ketone and focused ultrasound are both effective in the treatment of high-risk HPV infection with or without CINI,especially the combined treatment is better than the single regimen,in which focused ultrasound has a significant effect on the short-term negative conversion of HPV and the reversal of CINI,and Phytic acid ketone is more significant in the long-term negative conversion of HPV infection.Anxiety scores in each group decreased significantly after treatment,indicating that both drug therapy and physical therapy can improve patients’ anxiety state,and the effect of focused ultrasound plus Phytic acid ketone on improving anxiety was significantly higher than that of other treatment groups.Therefore,Phytic acid ketone and focused ultrasound are worthy of clinical promotion.