Clinical Efficacy Of Sacubitril-valsartan In The Treatment Of Chronic Heart Failure Complicated With Paroxysmal Atrial Fibrillation

Purpose: To investigate the effect of sacubitril-valsartan on cardiac function and recurrence of atrial fibrillation in chronic heart failure complicated with paroxysmal atrial fibrillation.Method: A total of 84 inpatients with chronic heart failure and paroxysmal atrial fibrillation who were treated in Nanchang First Hospital from 2019 to 2021 were selected.Conventional heart failure drugs combined with sacubitril and valsartan were used as the experimental group,and conventional heart failure drugs were selected as the experimental group.The treatment was the control group,with42 cases in each group.The treatment was observed for 6 months,and the left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left atrial diameter(LAD),and B-type brain sodium were compared between the two groups before and after treatment.Peptide precursor(NT-pro BNP),heart rate(HR),P wave dispersion(ΔP),C-reactive protein(CRP),homocysteine level(Hcy),estimated glomerular filtration rate(e GFR)level changes.Result: After 6 months of treatment,LVEF,LVESD,LVEDD,LAD,NT-pro BNP,HR,△ P and Hcy in the experimental group were significantly improved compared with those before treatment(P<0.05);CRP and e GFR were decreased compared with those before treatment,and the difference was not statistically significant significance(P>0.05).In the control group,LVESD,LVEDD,LAD,NT-pro BNP,and △ P were significantly improved compared with those before treatment(P<0.05);HR,LVEF,CRP,Hcy,and e GFR were improved compared with those before treatment,but the difference was not statistically significant(P>0.05).And after treatment,the LVESD,LAD and △ P of the experimental group were improved more obviously than those of the control group,P<0.05.Conclusion: Compared with traditional drugs,sacubitril-valsartan can improve cardiac function in patients with chronic heart failure and paroxysmal atrial fibrillation,inhibit cardiac remodeling,possibly reduce the recurrence of paroxysmal atrial fibrillation,and have no significant effect on renal function.