Difference In Efficacy Of Oral Propranolol For Infantile Hemangiomas In Different Facial Parts

Objective:We found differences in the efficacy of oral propranolol in children with facial IH in clinical treatment.But what causes the difference is unclear.This study is to collect the data of oral propranolol in children with facial hemangioma and group according to gender,hemangioma classification,starting time of medication,duration of medication,area and location of hemangioma and risk degree through the retrospective study.This study is to explore the factors that may affect the efficacy of oral propranolol in patients with facial hemangioma.Methods:We collected the date with facial infantile hemangiomas treated in the First Affiliated Hospital of Gannan Medical University during May 1,2017 to May 1,2020 by prospective design.The children with facial infantile hemangiomas were divided into group according to gender,the degree of risk,the depth of the lesion,location and the region of the lesion.Then the efficacy of those datas are measured.Statistical Pearson Chi-Square,Logistic regression model analysis and rank sum test was performed for different groups.Then Discuss and analyze the influence of each factor on curative effect.Results:1.156 children were included in the study,including 51 males and 105 females.And the ratio of female-to-male was 2.06:1.The effective rates of male and female children respectively were 90.20%,91.43%,The difference of effective rates between different gender was not statistically significant.3.According to different regions of distribution,The facial infant hemangioma were grouped into frontonasal(orbital,frontal,nasal,nasolabial,sulcus),frontotempora(upper and lower eyelids,inner and outer canthus),maxillary(upper lips,cheeks),mandibular(lower lip,lower chin,periauricular area,parotid gland).and the effective rates of them respectively were 81.81%,96.67%,94.87%,96.00%.The difference of effective rates among region was not statistically significant.The children with facial infantile hemangiomas were divided into seven grounp according to the location,including Forehead,eye,nose,mouth,cheek,parotid gland,ear.The effective rates of them respectively were 91.67%、96.67%、80.95%、89.74%、95%、93.33%、100%.The difference of effective rates between area was not statistically significant.4.According to the degree of risk of facial infantile hemangioma,the effective rate of moderate risk group and high risk group was 98.36% and 88.54% respectively.the difference of curative effect was statistically significant.5.The children with facial infantile hemangiomas were divided into superficial type,mixed type and deep type according to type of the depth.The effective rates of small,middle and large size respectively were 93.94%,91.43%,86.36%.The difference of effective rates among different size was not statistically significant.6.According to the treatment time of facial infantiles hemangioma,the effective rates of less than 5 weeks,5 weeks to 6 months and more than 6 months were100%,97.06% and 79.07% respectively,and the difference in efficacy was statistically significant.There was no statistically significant difference between less than 5 weeks and 5 weeks to 6 months.But the regression rate of less than 5 weeks was higher than5 weeks to 6 months.7.According to the types of facial infantile hemangioma lesions,the focal and segmental effective rates were 93.75% and 75% respectively.And the difference in efficacy was statistically significant.8.Facial infantile hemangiomas were divided into groups according to the treatment period.There were statistically significant differences in the regression rates between the group less than 6 months and the group from 6-7 months and the group from 7-9 month.There were no statistically significant differences in the regression rates between the group from 6 months and the group from 9 months.There were no statistically significant differences in the regression rates among the group from 6-7months,7-9 months,9 months.Conclusion:The different degree of risk,the treatment time and the treatment period of facial infantile hemangioma were the factors that affected the efficacy of facial infants hemangioma.After the exclusion of contraindications,treatment should be started as soon as possible,and the time of oral medication should be well controlled.The optimal treatment duration is about 7 months.Prolonged treatment time does not significantly increase the facial hemangioma regression rate.