| Purpose: To explore the relationship between brachial-ankle pulse wave velocity and microvascular complications of type 2 diabetes mellitus.Method: Type 2 diabetes patients hospitalized in the Department of Endocrinology,the Third Affiliated Hospital of Nanchang University from 2019 to 2021 were selected as the research object.After our screening and statistics,a total of 322 patients with type 2 diabetes were selected.After the patient was admitted to hospital,we collected medical history,personal information of the patient.We asked about the duration of diabetes and previous medical history of the patient,recorded the height and weight of the patient at the time of admission to further calculate the body mass index,and collected blood samples of the patient for biochemical tests in relevant laboratories.Urine samples were collected from patients in the morning,urine creatinine and urine microalbumin were detected,and then the calculation and unit conversion were carried out.All the selected patients underwent fundus photography,nerve conduction examination and sensory threshold measurement.We measured the pulse wave velocity of both sides of arm and ankle and calculated the average value.According to the velocity of brachial-ankle pulse wave,the selected cases were divided into two groups: Group 1(lower than the reference cutoff value,n=160)and Group 2(higher than the reference cutoff value,n=162).We choosed SPSS 25.0 as the statistical analysis software and observed the relationship between brachial-ankle pulse wave velocity and microvascular complications of type 2 diabetes mellitus.Results: 1.Comparison of basic data: there were no significant differences in age,sex,body mass index,2-hour postprandial blood glucose,fasting C-peptide,2-hour postprandial C-peptide,glycosylated hemoglobin,triglyceride,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,total cholesterol,serum creatinine,smoking and drinking history between the two groups(p>0.05);Compared with group 1,systolic blood pressure,diastolic blood pressure,duration of diabetes,fasting blood glucose,urea nitrogen and blood uric acid in group 2increased significantly(p<0.05).The prevalence of diabetic retinopathy,peripheral neuropathy and nephropathy in group 2 was significantly higher than that in group 1,and the difference was statistically significant(p<0.05).2.Patients were grouped according to whether or not they had type 2 diabetic peripheral neuropathy.The results showed that the brachial-ankle pulse wave velocity was significantly increased in the type 2 diabetic peripheral neuropathy group,and the difference was statistically significant(p=0.003).There was no significant difference in mean arterial pressure and age between the two groups(p >0.05);According to the grouping with or without type 2 diabetic nephropathy,the results showed that the brachial-ankle pulse wave velocity and mean arterial pressure in the type 2 diabetic nephropathy group were significantly increased,and the differences were statistically significant(p=0.000),and there was no significant difference in age between the two groups(p>0.05);The patients were grouped according to whether or not they had type 2 diabetic retinopathy,and the differences between the two groups were compared.The results showed that the brachial-ankle pulse wave velocity of the group with type 2 diabetic retinopathy was significantly higher than that of the group without type 2 diabetic retinopathy,and the difference was statistically significant(p=0.000).The difference in mean arterial pressure and age between the two groups was not statistically significant(p>0.05).3.Multivariate logistic regression analysis was conducted with each factor as the independent variable,the brachial-ankle pulse wave velocity grouping(Group 1and Group 2)as the dependent variable and Group 1 as the reference group.The results showed that the diastolic blood pressure {OR 1.039(1.010-1.068)p=0.008},the duration of diabetes {OR 1.059(1.017-1.103)p=0.006},the fasting blood glucose{OR 1.104(1.025-1.188)p=0.009},and the urea nitrogen {OR 1.128(1.001-1.270)p=0.048} were all independently related to the brachial-ankle pulse wave velocity.Conclusion: 1.Compared with the group with the brachial ankle pulse wave velocity below the reference cut-off value,the systolic blood pressure,diastolic blood pressure,diabetes duration,fasting blood glucose,urea nitrogen and blood uric acid in the group with the brachial ankle pulse wave velocity higher than the reference cut-off value significantly increased,and the prevalence of peripheral neuropathy,nephropathy and retinopathy in type 2 diabetes also significantly increased.2.Compared with patients without microvascular complications of type 2diabetes mellitus,the brachial-ankle pulse wave velocity of patients with peripheral neuropathy,nephropathy and retinopathy of type 2 diabetes mellitus increased significantly.3.The diastolic pressure,the fasting blood glucose,the urea nitrogen and the duration of diabetes mellitus were independent risk factors of the brachial-ankle pulse wave velocity. |
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