The Neuropsychological Characteristics Of Cognitive Impairment In Patients With Cerebral Small Vessel Disease

Objective:To explore the neuropsychological characteristics of cognitive impairment in patients with cerebral small vessel disease,and to provide evidence for early clinical detection of cognitive impairment.Methods:The case group selected 72 patients with lacunar infarction,one of the subtypes of cerebral small vessel disease clearly diagnosed from September 2020 to September 2021 in the First Hospital of Shanxi Medical University,the control group selected 72 patients of the same sex,same age and same education level treated in our hospital in the same period.The past medical history data of the patients were collected,including the presence or absence of hypertension,diabetes,hyperlipidemia,hyperhomocysteinemia and other medical history.Line to both groups of objects Cognitive impairment Montreal cogintive assessment,Clock drawing test(CDT),Trail making test(TMT),Hopkins Test of Language Learning(HVLT).The differences between the two groups of each scoring scale were compared,and the neuropsychological characteristics of patients with cerebral small vessel disease were discussed.Results:1.The proportion of hypertension and hyperhomocysteinemia in the cerebral small vessel disease group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the prevalence of diabetes and hyperlipidemia between the two groups of patients(P>0.05).2.The total score of the Mo CA in the cerebral small vessel disease group was lower than that in the control group,and there were differences in the scores of visuospatial and executive function,language ability,and abstract thinking function between the two groups(P<0.05).There was no significant difference in the scores of naming,delayed recall,attention,and orientation between the two groups of patients(P>0.05).3.The CDT10 score of the patients with cerebral small vessel disease group was lower than that of the control group,and the time-consuming of TMT-B in the connection test was more than that of the control group(P<0.05).There was no significant difference in TMT-A time consumption and HVLT-R score between the two groups(P>0.05).Conclusion:1.The overall cognitive function of patients with cerebral small vessel disease will be impaired,which is mainly reflected in the aspects of language,abstract thinking,and visuospatial executive function.2.Montreal Cognitive Assessment Scale-Beijing version,clock-drawing test and trail making test are more sensitive for the screening of cognitive decline in patients with cerebral small vessel disease.