Analysis Of Risk Factors For Lung Cancer Complicated With Venous Thrombosis In Xuanwei Yunnan

ObjectivesBy collecting and summarizing the clinical characteristics of patients with lung cancer combined with venous thromboembolism in Xuanwei,analyzing the risk factors for thrombosis and related factors affecting blood hypercoagulability,and exploring the relationship between lung cancer and venous thromboembolism in Xuanwei Yunnan.Provide reference for prevention of venous thrombosis in patients with lung cancer.MethodsThe basic clinical information of 153 patients diagnosed with lung cancer in Yunnan First People’s Hospital from January 2013 to April 2021 were collected,and they were divided into VTE group(32 cases)and non-VTE group(121 cases)according to the occurrence of venous thrombosis.The general clinical information(sex,age,smoking history,co-morbidities,BMI,urban and rural distribution,lung cancer characteristics),laboratory indicators(blood cells,blood lipids,tumor markers,coagulation indicators)of patients were compared between groups.The chi-square test,rank sum test,binary logistic regression and linear regression were performed by SPSS22.0 software to analyze the risk factors of lung cancer complicated with VTE and the related risk factors of blood hypercoagulability.Results1.Comparison of basic information between VTE group and non-VTE group:there were significant differences in smoking index and pathological type between the two groups(P<0.05),but no significant differences in gender,age,co-morbidities,lung cancer stage and metastasis,urban and rural distribution,and MBI.(P>0.05).2.Comparison of laboratory indexes between VTE group and non-VTE group:HB,CYFRA21-1,CEA,FIB,D-D2 were significantly different(P<0.05).The above indexes were included in the binary Logistic regression analysis,and the results showed that D-D2(OR=3.377,95%Cl 1.763-6.648,P <0.01)was an independent risk factor for lung cancer patients with VTE in Yunnan.3.Comparison of clinical features and coagulation indexes of lung cancer: FIB and FDP were significantly different among pathological types,and FIB of adenocarcinoma was higher than that of squamous cell carcinoma between groups(P<0.05);FDP,FIB,and D-D2 were significantly different in lung cancer.There were significant differences between the stages,and the D-D2 and FDP of the advanced lung cancer were higher than those of the early stage(P<0.05).The D-D2,FIB and FDP of the disease were significantly higher than those without the disease(P<0.05).4.Linear regression analysis: age was positively correlated with D-D2(B:1.548P<0.05);lung cancer stage,distant metastasis,neutrophils,hemoglobin were positively correlated with FIB(B:1.894,2.232,respectively),1.417,1.817,P<0.05);neutrophils were positively correlated with FDP(B:1.435 P<0.05);BMI,urban/rural were negatively correlated with FDP(B value:-0.639,-5.421 P<0.05).5.Thromboembolism in the VTE group: 18 cases of venous thrombosis were diagnosed when lung cancer was diagnosed;6 cases were diagnosed with venous thrombosis 2 weeks after lung cancer surgery;8 cases were diagnosed with venous thrombosis after radiotherapy and chemotherapy;the incidence of thrombus within 1month after diagnosis of lung cancer was 75 %,and the incidence of thrombosis within2 months of diagnosis was 87.5%.Conclusions1.The majority of patients with lung cancer complicated with VTE in Xuanwei are smokers,and the pathological diagnosis of adenocarcinoma in common.Patients with advanced lung cancer,complicated with multiple diseases and elevated neutrophils show hypercoagulability.2.When D-D2,FIB,CYFRA21-1,CEA and HB are elevated in the serology of lung cancer patients in Xuanwei,the risk of thrombosis is increased.3.The 2 months before diagnosis and treatment of lung cancer is the high-risk period for venous thrombosis.