Meta-analysis Of The Clinical Effect Of Addition And Subtraction Of Xiaoyao Powder On Insomnia

Objective: Objective and accurate analysis and evaluation of Xiaoyao powder in the clinical treatment of insomnia about efficacy and safety issues,for Xiaoyao powder in the clinical treatment of insomnia to provide reliable evidence for systematic evaluation.Methods:Design paper retrieval strategy,determine key words or topics,search Chinese and English databases,the databases include: full-text database of Chinese academic journals,full-text database of Weipu Chinese sci-tech journals,Wanfang database,Chinese biomedical database,Pubmed,The Cochrane Library and Embase.The search time was limited to January2009 to December 2009,and the inclusion criteria were developed.The literature was selected by two researchers independently to determine the final inclusion.The basic characteristics of the literature and the experimental data were extracted by Excel,meta-analysis summary and discon using Review manager 5.4 statistical software provided by the Cochrane collaboration.Results:A total of 29 articles were included in this study,including 2261 patients,including 1136 in the trial group and 1125 in the control group.The ratio of male to female was about 07:1.Meta-analysis showed:1.Clinical cure rate(Xiaoyao powder plus or minus 对 比 Western Medicine): combined effect RR = 1.89,95% CI(1.57,2.28),Z test: Z =6.65,P< 0.01;clinical cure rate(xiaoyao powder plus or minus plus Western medicine 对 比 Western Medicine): combined effect RR = 1.69,95% CI(1.37,2.07);Z TEST: Z = 4.99,P<0.01.2.PSQI score(Xiaoyaosan plus minus 对 比 Western Medicine): MD =0.25,95% CI(-0.32,0.83),Z test: Z = 0.87,P = 0.38;PSQI score(Xiaoyaosan plus minus + Western medicine 对 比 Western Medicine): MD =-3.33,95% CI(-4.18,-2.48),Z test: Z = 7.67,P<0.01.;3.Tcm Syndrome Integral: combined effect SMD =-4.00,95% CI(-6.00,-1.99),Z test: Z = 3.91,P < 0.01;4.Side effects(Xiaoyao powder plus or minus 对 比 Western Medicine):combined effect rr = 0.19,95% CI(0.11,0.33),Z test: Z = 5.87,P <0.01;side effects(Xiaoyao powder plus or minus + Western medicine 对 比Western Medicine): combined effect rr = 0.44,95% CI(0.15,1.30),Z test:Z = 1.49,P= 0.14.Conclusion: 1.The clinical effect of Xiaoyao powder on insomnia was better than that of Western medicine;2.Xiaoyao powder is an effective and safe clinical treatment for insomnia.