Analysis Of Clinical Features Of Children With Acute Gastroenteritis Infection With Norovirus In Changchun City,2020-2021

Objective:To analyze the clinical features and laboratory examination of children with acute gastroenteritis caused by simple norovirus and norovirus combined with rotavirus,compare the differences in clinical features between children with acute gastroenteritis caused by Norovirus infection alone and Norovirus combined with rotavirus infection,so as to improve the understanding of Norovirus infection and provide some guidance for clinical diagnosis and treatment.Methods:The clinical case data of 612 children with norovirus infection of acute gastroenteritis admitted to Changchun Children’s Hospital from January 2020 to June2021 were included.The subjects were selected through the inclusion criteria and exclusion disease.Application spss26.0 statistical software makes statistics and Analysis on the obtained data,and the difference is statistically significant（P<0.05）.Results:1.There were significant differences in sex and age distribution between children with acute gastroenteritis with simple norovirus infection and children with acute gastroenteritis with norovirus combined with rotavirus infection.Among them,younger boys were more likely to develop norovirus combined with rotavirus infection.2.Of the 191 pure norovirus infections in 2020,11 were in spring,11 in summer,92 in autumn and 77 in winter.Most of the infections occurred in autumn and winter festivals,accounting for 88.5%（169/191）.3.Vomiting was the most common in 332 children with acute gastroenteritis in267（80.4%）.With diarrhea 180（54.2%）,fever 173（52.1%）,respiratory symptoms158（47.6%）,myocardial damage 150（45.2%）,abdominal pain 104（31.3%）,dehydration 90（27.1%）,incomplete intestinal obstruction 47（14.2%）,and electrolyte disturbances 3（0.9%）.4.Among the 332 study subjects,WBC increased of 198 cases（59.6%）,No change of 126 cases（38.0%）,and reduced of 8 cases（2.4%）;The elevated h CRP was72 cases（21.7%）and elevated PCT was 52 cases（15.7%）.Some children had different degrees of elevated myocardial enzymes,including 138 cases elevated creatine kinase isozyme（41.6%）,30 cases elevated creatine kinase（9.0%）,and 186cases elevated lactate dehydrogenase（56.0%）.124 cases（37.3%）children were accompanied by decreased CO₂CP.5.The simple norovirus infection group had lower in fever,diarrhea,dehydration,respiratory symptoms,myocardial damage and higher abdominal pain than the norovirus plus rotavirus infection group,with significant difference（P<0.05）;There was no significant difference in vomiting,electrolyte disturbance and incomplete intestinal obstruction between the two groups（P>0.05）.6.The length of stay fluctuated from 2 to 13 days,with an average of 6 days.The prognosis was good.Conclusion:1.In this study,there were significant differences in gender and age between the two groups,and younger boys were more likely to develop norovirus combined with rotavirus infection.2.Norovirus infection is seasonal,mainly in autumn and winter.3.The most prominent clinical manifestation of children with norovirus infection with acute gastroenteritis is vomiting,followed by diarrhea,fever,abdominal pain,etc.4.About half of the children with norovirus infection of acute gastroenteritis had elevated WBC.h CRP and PCT increased and CO₂CP decreased in a few children.The increase of myocardial enzymes was mainly caused by the increase of CK-MB and LDH.5.The simple norovirus infection group was lower than norovirus plus rotavirus infection group in fever,diarrhea,dehydration,respiratory symptoms,and myocardial damage;higher than norovirus plus rotavirus infection group in abdominal pain;not significant in vomiting,electrolyte disorder,and incomplete intestinal obstruction.6.The child patient average hospital stay was 6 days,and the prognosis was good.