Expression And Clinical Significance Of PCBP2 In Non-small Cell Lung Cancer

Objective: To investigate the expression of PCBP2 in NSCLC and its relationship with clinicopathological features and prognosis,and to explore the potential of PCBP2 as a prognostic assessment and effective therapeutic target in NSCLC.Methods:(1)101 cases of non-small cell lung cancer confirmed by pathology department were collected,including 50 cases of lung squamous cell carcinoma and 51 cases of lung adenocarcinoma.Immunohistochemical method(IHC)was used to detect the expression of PCBP2 protein in cancer tissues and adjacent tissues of 101 cases of non-small cell lung cancer.The correlation between PCBP2 protein expression and clinicopathological features was analyzed statistically.Graphpad Prism software was used to analyze the relationship between PCBP2 protein expression and postoperative 5-year survival rate in patients with non-small cell lung cancer.(2)The protein expression of PCBP2 in non-small cell lung cancer(NSCLC)and adjacent tissues was detected by Western Blot method in 4 fresh and surgically resected specimens,including lung cancer tissues and adjacent tissues.Results :(1)The results of IHC and Western Blot have showed that PCBP2 protein was highly expressed in NSCLC compared with adjacent lung tissues,which not related to tissue type(P = 0.613).(2)There was no significant correlation between PCBP2 protein expression and gender(P =0.318),age(P = 0.413),tumor differentiation(P = 0.514),TNM pathological stage(P = 0.124)in NSCLC(P > 0.05).The expression of PCBP2 was correlated with tumor size(P = 0.027)and lymph node metastasis(P = 0.031)(P< 0.05).(3)The five-year survival rate of patients with high expression of PCBP2 was lower than that of patients with low expression of PCBP2,the difference was statistically significant(P < 0.001).Conclusion:(1)PCBP2 is highly expressed in non-small cell lung cancer,and was not related to tissue type.(2)PCBP2 expression is correlated with tumor size and lymph node metastasis.(3)High expression of PCBP2 is associated with poor prognosis,and PCBP2 can be used as one of the prognostic indicators for patients with NSCLC.