Correlation Of Adiponectin And Early Renal Damage In Patients With Essential Hypertension

Objective: This study aimed to inquire into the relevance between blood serum adiponectin(APN)concentration and early stage renal damage in patients with essential hypertension.Method: A total of 200 patients with essential hypertension were collected as study subjects,125 males and 75 females.The necessary clinical data of the subjects were collected,the relevant biochemical indexes were measured,and the level of serum APN was detected by ELISA.Then the patients weredivided into normal renal function group(105 cases)and impaired renal function group(95 cases)on the basis of estimated glomerular filtration rate(e GFR)level.The differences of various indexes between the two groups were compared,and the correlation between EGFR and various indexes was analyzed.Multivariate logistic regression was used to clarify the relationship between APN and early renal damage in patients with essential hypertension.Results: Serum APN in patients with impaired renal function [4.10(2.68,7.30)](μg·ml-1)was significantly higher than that in normal renal function group [3.48(2.29,4.53)](μg·ml-1).HDL-C,SCR,UA and Cys C in the group with impaired renal function were higher than those in the group with normal renal function,while TG,TC and EGFR were significantly lower than those in the group with normal renal function(P<0.05).There was no significant difference in gender,age,BMI,FBG and LDL-C between the two groups(P>0.05).The results of correlation analysis showed that e GFR was negatively correlated with age,HDL-C,SCr,UA,Cys C and APN,but positively correlated with TG,TC,LDL-C(P<0.05).After adjusting for age and BMI,EGFR was still negatively correlated with APN(partial correlation number r=-0.279,P=0.001).Multivariate logistic regression analysis showed that increasing age(OR=1.197,95%CI=1.130-1.267),elevated UA(OR=1.009,95%CI=1.003-1.014),elevated Cys C(OR=3.423,95%CI=1.046-11.203)and elevated APN were risk factors for early renal function impairment in patients with essential hypertension(P<0.05).Conclusion: There is a correlation between APN and early renal damage in patients with essential hypertension.The changes of APN levels in patients with essential hypertension could reflect transformation of renal function;The increase of APN is a risk factor of early renal damage in patients with essential hypertension.