Diagnostic Value Of Gd-IgA1 Combined With Multiple Indexes In The Diagnosis Of IgA Nephropathy

Objective:To explore the diagnostic value of Gd-Ig A1 combined with multiple indexes in Ig A nephropathy.Methods:The prospective research method was used to study84 patients with primary suspicious glomerulonephritis who underwent renal biopsy for the first time in the people’s Hospital of Xinjiang Uygur Autonomous Region from March2021 to December 2021.The clinical biochemical indexes and general indexes were collected,and venous blood was collected for the detection of serum GD Ig A1 ELISA.Finally,the specificity and sensitivity of each index were calculated.The area under each detection index curve was calculated by using ROC curve,and the laboratory indexes with more diagnostic value were summarized.The prediction probability values of multiple joint indexes were calculated by binary Logsitic regression,Then draw the receiver operating characteristic curve(ROC)curve and calculate the area under the curve to obtain the expected index.Results:In Ig AN patients,the level of serum GD Ig A1 was significantly higher than that in non Ig AN patients(P < 0.05).In logistic regression analysis,Gd Ig A1 was independently correlated with urinary protein and serum Ig A level.The diagnostic efficacy of the three indexes in the combined diagnosis of Ig A nephropathy was analyzed by ROC curve.When the sensitivity and specificity were 76.9% and 74.1% respectively,the area under the curve was 0.815(95% CI: 0.644-0.842,P < 0.05).Conclusions:Gd-Ig A1 can be used as a biomarker combined with multiple indicators to improve the diagnostic efficiency of Ig A nephropathy.