| Object:1.To explore the correlation between different MRI manifestations of cerebral small vessel disease and vascular cognitive impairment.2.Assessing risk factors associated with vascular cognitive impairment due to cerebral small vessel disease.Method:Patients with cerebral small vessel disease(CSVD)admitted to Hulunbuir People’s Hospital from December 2019 to December 2021 were collected,and the Montreal cognitive assessment scale(Mo CA)examination was completed for the selected patients.The cognitive function status was evaluated.Mo CA≤26 points were divided into cognitive impairment(CI)group with a total of 100 cases,and Mo CA>26 points were divided into noncognitive impairment(NCI)group with a total of 90 cases.The general clinical data(including gender,age,Mo CA score)and risk factors(hypertension,diabetes,hyperlipidemia),and white matter lesions(WML)of the two groups were compared between the two groups.The brain area score and the number of lesions in each brain area of lacunar infarction(LI)between the two groups were statistically different,and the risk factors of cognitive impairment in CSVD were analyzed.Result:1.The general clinical data of the two groups of subjects were statistically analyzed,and the results were that the average age of the CI group was(64.86±10.36)years old > the average age of the NCI group(61.97±9.67)years old,and the difference in age was statistically significant(P < 0.05),while there was no statistically significant difference in gender(P > 0.05).2.The risk factors of the two groups of patients were compared,and the results showed that there were 81 patients with hypertension in the CI combination > 49 patients with hypertension in the NCI combination,42 patients with diabetes in the CI combination > 25 patients in the NCI combination and diabetes.There were no differences between the two groups in total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),triglyceride(TG),blood isotype The comparison of cystine(Homocysteine,Hcy)was not statistically significant(P>0.05).3.Through statistical analysis of the number of lacunar infarcts in each brain region of the two groups of patients,the results showed that the average number of lacunar infarcts in the frontal lobe area of the CI group was 0.47±0.40 > the average number of lacunar infarction lesions in the frontal lobe area of the NCI group was 0.16±0.10.The average number of luminal infarction lesions in the temporal lobe area of the CI group was0.11±0.08 > the average number of luminal infarction lesions in the temporal lobe area of the NCI group was 0.06±0.02,and the average number of luminal infarction lesions in the parietal and occipital lobe area of the CI group was 0.37±0.30 > The average number of luminal infarction lesions in the parieto-occipital lobe area of the NCI group The number of luminal infarction lesions in the basal ganglia of the CI group was 0.03±0.01,the average number of luminal infarction lesions in the basal ganglia of the CI group was 2.23±1.25,and the average number of luminal infarction lesions in the parietal basal ganglia of the NCI group was1.26±1.03.There was a statistical difference between the two groups(P<0.05).There was no statistical difference between the two groups in the infratentorial area(P>0.05).4.The WML scores of each brain region of the two groups were compared: the average WML score in the frontal lobe region of the CI group was 0.30±0.28> the average WML score of the frontal lobe region of the NCI group was 0.11±0.07,and the average WML score of the parietal occipital lobe region of the CI group was 2.26±2.09> The NCI group The average score of WML in the parieto-occipital lobe area was 0.78±0.64,the average WML score in the basal ganglia in the CI group was 3.26±1.81,and the average WML score in the basal ganglia in the NCI group was 1.87±1.10.There was a statistical difference between the two groups(P<0.05).There was no statistical difference between the two groups in the temporal lobe area and the infratentorial area(P>0.05).5.Binary logistic regression analysis was performed on the collected CSVD risk factors,and the result showed that there were statistical differences in the history of diabetes analysis,while the other indicators failed the significance test standard of P<0.05.Conclusion:1.Cognitive impairment in patients with cerebral small vessel disease is related to age,and cognitive impairment is more likely to occur with age.2.The severity and location of WML as well as the number and location of LI lesions are associated with cognitive impairment in cerebral small vessel disease: LI in frontal lobe,temporal lobe,variety-occipital lobe,and basal ganglia is positively correlated with the severity of cognitive impairment,WML in the frontal lobe,variety-occipital lobe,and basal ganglia are also prone to cause cognitive impairment.3.Diabetes is a risk factor for CI in CSVD. |
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