Effect Of MECT Combined With SSRI In The Treatment Of Moderate To Severe Depression And Its Effect On Cognitive Function

Objective: Guided by the concept of precision medicine,this study focused on the analysis of efficacy and cognitive function.The Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD),Montreal Cognitive Assessment Scale(MOCA)and The Wisconsin Card Sorting Test(WCST)evaluates patients with mental disorders,and the efficacy and cognitive function changes of modified electroconvulsive therapy(MECT)combined with serotonin reuptake inhibitor(SSRI)therapy and SSRI alone in patients with moderate to severe depression Comparisons were made to provide some preliminary research basis for the treatment of moderate to severe depression.Methods: Selected patients with moderate to severe depression who met the diagnosis of(International Statistical Classification of Diseases and Related Health Problems,10 th Revision,ICD-10)in hospitalized patients with depression in the Inner Mongolia Autonomous Region Mental Health Center(Inner Mongolia Brain Hospital),and collected a total of 57 cases.First,collect their general information,including name,gender,age,years of education,number of electroconvulsive shocks,and drug use,and then divide the 57 patients into an experimental group and a control group according to the random number table method.Sexual electroconvulsive therapy,the control group received drug treatment alone,and after the guidance and training of two psychiatric superior physicians,the two groups of patients were regularly assessed the Hamilton Depression Scale,Hamilton Anxiety Scale,Wisconsin Card Sorting Test and Montreal Cognitive Function Test,to reflect the emotional and cognitive function of the patients,the evaluation time of the experimental group was before the modified electroconvulsive treatment,4 hours after the third treatment of the modified electric shock,and 4 hours after the eighth treatment of the modified electric shock.Assessments were also made at the same time.The changes in emotion,clinical symptoms and cognitive function of the two groups of patients during the treatment process were observed,and the general information,the total scale scores and the scores of each factor of the two groups of patients were recorded,and SPSS19.0 software was used to analyze the relevant experimental data.For processing,the chi-square test was used for the comparison of enumeration data,the mean ± standard deviation was used for measurement data,and the independent sample t test and rank sum test were used,and p<0.05 was considered statistically significant.To observe the comparison of the clinical efficacy of modified electroconvulsive therapy combined with drug therapy and single drug therapy,as well as the influence of treatment on the overall and specific aspects of the patient’s cognitive level,whether this effect increases with the increase of treatment time and the number of modified electroconvulsive therapy changes.Result:(1)The experimental group was compared with the control group in the Hamilton Depression Scale-24 scale score 4 hours after the third treatment of modified electroconvulsive shock(P<0.05).(2)Comparing the experimental group and the control group in the Hamilton Depression Scale-24 scale score 4 hours after the eighth treatment of modified electrical shock,there were significant differences between the two groups in terms of total score,block,and sense of hopelessness(P<0.01);there were statistical differences in the factor scores of anxiety somatization,day-night changes,and sleep disorders(P<0.05).(3)There was a statistical difference between the experimental group and the control group in the scores of Hamilton Anxiety Scale-14 before modified electroconvulsive therapy and the scores of mental anxiety factors between the two groups(P<0.05).(4)Compared with the control group,the Hamilton Anxiety Scale-14 scale score 4hours after the third modified electroconvulsive therapy was compared,and there were significant differences between the two groups in terms of total score and mental anxiety(P<0.01).(5)The experimental group was compared with the control group in the Hamilton Anxiety Scale-14 scale score 4 hours after the eighth session of modified electroconvulsive therapy.Compared with the two groups in terms of total score,mental anxiety,and somatization anxiety,there were significant differences.difference(P<0.01).(6)Comparing the scores of the Montreal Cognitive Function Rating Scale between the experimental group and the control group before modified electroconvulsive therapy,there was a significant difference in the total score between the two groups(P<0.01);factors in attention and naming There was a statistical difference(P<0.05).(7)Comparing the scores of the Montreal Cognitive Function Rating Scale 4 hours after the third treatment of modified electrical shock between the experimental group and the control group,there were significant differences in the naming factor scores between the two groups(P<0.01);Compared with the factor scores,there was a statistical difference(P<0.05).(8)Comparing the Montreal Cognitive Function Rating Scale scores between the experimental group and the control group 4 hours after the eighth treatment of modified electrical shock,there were significant differences between the two groups in the factor scores of total score,memory and abstract ability(P<0.01);there was a statistical difference in the factor scores of attention and language(P<0.05).(9)There was a statistical difference between the experimental group and the control group in the Wisconsin Card Sorting Test scores before the modified electroconvulsive therapy(P<0.05).(10)Comparing the scores of the Wisconsin Card Sorting Test 4 hours after the third treatment of modified electroshock between the experimental group and the control group,there was a statistical difference between the two groups in the persistent error and persistent error percentage factor score(P< 0.05).Conclusion:(1)The modified electroconvulsive combined with serotonin reuptake inhibitor treatment group had better effect in improving depression and anxiety than the serotonin reuptake inhibitor treatment group alone.(2)The modified electroconvulsive combined with serotonin reuptake inhibitor treatment group had better effect on cognitive function improvement than the serotonin reuptake inhibitor treatment group alone.