Comparison Between Contrast-Enhanced Ultrasound And Enhanced Magnetic Resonance Imaging In Indeterminate Ovarian-Adnexal Masses

ObjectiveTo compare the diagnostic value of contrast-enhanced ultrasound(CEUS)and enhanced magnetic resonance imaging(MRI)in indeterminate ovarian-adnexal masses.At the same time,the accuracy of diagnosis before and after combining patient history and tumor markers was compared.MethodsCEUS and MRI were performed on 46 cases of sonographically indeterminate ovarian-adnexal masses.Two independent sonographers and two radiologists reviewed the images before and after combining with clinical history or/and the serum tumor markers(including CA-125,CA-199,HE4 and AFP)respectively.The results of CEUS and MRI were compared with the pathologic findings(43 cases)or follow-up after clinical treatment(3 cases)as gold standard.ResultsThe diagnostic accuracy of CEUS in indeterminate ovarian-adnexal mass was 67.4%without combining the history and tumor markers,which was lower than 80.4%of MRI.There was significant difference(P<0.05).However,there was no significant difference between them in combination with tumor markers or/and combination with the history(P>0.05).The accuracy of CEUS combined with history and tumor markers in diagnosing ovarian-adnexal masses was 91.3%,which was statistically different from CEUS without any histories(P<0.05).ConclusionCEUS combined with clinical history and tumor markers shows a potential value in differentiating between malignant and benign ovarian-adnexal masses and is comparable to that of MRI.