Analysis Of The Relationship Between Soluble Transferrin Receptor And Systolic Hypertension Based On NHANES

Background:Hypertension increases the global burden of disease and mortality.Iron metabolism is considered to be an important factor in hypertension.Although previous studies have analyzed the relationship between markers of iron metabolism and hypertension,the conclusions are inconsistent.Serum ferritin(SF)is susceptible to other factors,such as inflammation,soluble transferrin receptors(sTfR)is less affected by inflammation.Moreover,sTfR can better reflect the true state of iron metabolism.Therefore,it is necessary to further explore the relationship between sTfR and hypertension.Objective:This study explored the relationship between sTfR and hypertension through data mining and analysis,and the relationship between sTfR and systolic hypertension and diastolic hypertension.Materials and methods:A case-control study design was used to analyze the cross-sectional data of 7416 adults aged 20 and over in the National Health and Nutrition Survey(2007-2010 and 2015-2018).Statistical analysis and mapping using R 4.1.21.The weighted t-test was used to analyze the continuous variables,and the weighted chi-square test was used to analyze the classified variables.2.The correlation between iron metabolism markers and hypertension,diastolic hypertension and systolic hypertension was studied by weighted logistic regression analysis.At the same time,trend testing was used to analyze the trend of changes between sTfR and the incidence of hypertension.3.The nonlinear relationship between soluble transferrin receptor and systolic blood pressure was studied by using restricted cubic spline(RCS).4.Subgroup analysis and interaction analysis were used to further verify the correlation between sTfR and the prevalence of systolic hypertension.Results:1.According to The Seventh Report of the Joint National Committee on Prevention,Detection,Evaluation,and Treatment of High Blood Pressure(JNC 7),7416 subjects were included in this study,of which 1077(14.52%)had hypertension.2.Hypertensive participants had higher levels of hemoglobin(Hb),SF,and sTfR,while there was no significant difference in serum iron(SI).3.The results of weighted logistic regression showed that after adjusting for all potential confounding factors,higher sTfR levels were associated with higher prevalence of hypertension(OR=1.05;95%CI:1.01-1.05;P=0.001).At the same time,weighted logistic regression analysis showed that sTfR was an independent risk factor for systolic hypertension after adjusting for various confounding factors(P=0.009).4.The RCS results show that there was a nonlinear correlation between soluble transferrin receptor and systolic blood pressure.5.Among female and poor participants,sTfR was significantly associated with the prevalence of systolic hypertension.No interaction was found between sTfR and other covariates.Conclusion:1.Compared with non-hypertensive participants,hypertensive participants had higher levels of Hb,SF,and sTfR.2.sTfR was an independent risk factor for hypertension and also an independent risk factor for systolic hypertension.3.A non-linear relationship between sTfR and SBP was discovered.