Psychosocial Factors And Event-related Potential P300 Of Non-suicidal Self-injury In Children And Adolescents With Depressive Disorder

Objective: To understand the current situation of non-suicidal self-injury(NSSI)in children and adolescents with depression,and to explore the psychosocial factors of NSSI behavior and the changes of event-related potential P300 in children and adolescents with depression.Methods: The patients hospitalized in the Department of Child and Adolescent Psychology of Dazhuang Hospital in Shandong Province from February 22.6 to December 2019 were selected as the study objects.Adolescent non-suicidal self-injury questionnaire was used to evaluate the situation of the participants.According to the evaluation results,the subjects were divided into two groups: non-NSSI behavior group and NSSI behavior group.Psychological information was collected by self-designed general questionnaire,Toronto alexithymia scale(TAS-20),Barrett impulsive Personality questionnaire(BIS-11),simplified coping style questionnaire(SCSQ),Chinese version of Family Environment scale(FES-CV),Hamilton Depression scale(HAMD-24)and Hamilton anxiety scale(HAMA).The auditory event-related potential P300 of patients in each group was evaluated by Japanese photoelectric EMB-2306 EMG evoked potential instrument,and all the collected data were statistically analyzed by SPSS25.0 software.Results:1.In this study,a total of 115 children and adolescents with depressive disorder completed all psychological questionnaires and auditory event-related potential P300 evaluation,including 84 patients with NSSI behavior and 31 patients without NSSI behavior.The incidence of depressive disorder NSSI behavior in children and adolescents was the highest in 14-year-old patients(26).There were more females(69)than males(15)with NSSI behavior.The most common way to hurt yourself is to pinch yourself on purpose.The most common purpose of implementing NSSI behavior is to relieve anxiety and depression.There was no significant difference in gender,family residence,parents’ marital status,only child,left-behind experience,school bullying and family history between non-NSSI behavior group and NSSI behavior group(P > 0.05).Compared with the group without NSSI behavior,the group with NSSI behavior was often accompanied by psychotic symptoms,and the difference was statistically significant(P<0.05).The HAMD-24 total score of the group with NSSI behavior was significantly higher than that of the group without NSSI behavior,and the difference was statistically significant(P<0.05).2.The total score of alexithymia,difficulty in recognizing and describing one’s emotion in the group with NSSI behavior was significantly higher than that in the group without NSSI behavior(P <0.05).3.The total scores of impulsiveness,motor impulsiveness,unplanned impulsiveness and cognitive impulsiveness in the group with NSSI behavior were significantly higher than those in the group without NSSI behavior(P < 0.05).4.The scores of family independence and moral and religious values in the group with NSSI behavior were significantly higher than those without NSSI behavior(P < 0.05).5.The score of positive coping style in the NSSI behavior group was lower than that in the non-NSSI behavior group,and the difference was statistically significant.There was no significant difference in negative coping style between the two groups(P > 0.05).6.The results of binary logistics analysis showed that the total score of HAMD-24(or=1.29,P=0.011),psychotic symptoms(or=0.16,P=0.016),unplanned impulsiveness(or=0.21,P=0.03)and independence(or=12118.34,P=0.04)factors entered the regression equation of NSSI behavior response factors in turn.7.The auditory P3 a latency and P3 b latency of the NSSI behavior group were significantly longer than those of the non-NSSI behavior group,and the P3 a amplitude and P3 b amplitude were significantly lower than those of the non-NSSI behavior group,and the difference was statistically significant(P<0.05).Conclusion: The occurrence of NSSI behavior is related to anxiety,depression,psychotic symptoms,impulsiveness,alexithymia,family relationship and coping style,and the total score of HAMA-24,psychotic symptoms,unplanned impulsiveness and the independence of family members are the independent influencing factors.Children and adolescents with depressive disorder with NSSI behavior may have a significant decrease in attention and memory compared with those without NSSI behavior.