Clinical Efficacy Observation Of Fuyang Xuanbi Decoction In Treatment Of Elderly Degenerative Lumbar Spinal Stenosis (Cold-dampness Type)

Objective:The purpose of this study is to observe the clinical efficacy of Fuyang Xuanbi Decoction in the treatment of degenerative lumbar spinal stenosis(cold dampness obstruction type),evaluate the improvement of main symptoms of patients with this disease and the impact of Fuyang Xuanbi Decoction on serum inflammatory factor levels,and further verify the effectiveness and scientific nature of Fuyang Xuanbi Decoction.Methods:Sixty patients with degenerative lumbar spinal stenosis were selected as observation objects,and they were randomly divided into control group and research group,with 30 cases in each group,the control group took oral meloxicam tablets and methylcobalamin tablets for 4 weeks,and the research group took oral Fuyang Xuanbi Decoction for 4 weeks.Before treatment and 4 weeks after treatment,claudication distance evaluation,TCM syndrome scores,quality of life scores,and serum inflammatory factor levels were recorded for the observation subjects.VAS scores were followed up 1 month after drug withdrawal to compare the changes in various scores and serum inflammatory factor(IL-1β、hs-CRP、ESR)levels of the two groups at each time point.Results:There was no significant difference between the two groups before treatment in general information and observation indexes.① The effective rate of the study group was 89.29%,and the effective rate of the control group was 66.67%,and the difference in efficacy between the two groups was statistically significant.②In terms of VAS score,the VAS score after 2 weeks and 4 weeks of treatment was improved compared with before treatment,and the difference was statistically significant.After 2 weeks of treatment,the control group had significantly better VAS scores than the study group,and after 4 weeks of treatment,there was no significant difference in VAS scores between the two groups.After 1 month of discontinuation,the VAS score of the control group was significantly higher than before,and the difference was statistically significant,while the VAS score of the study group did not change significantly compared with the previous one,and the difference was not statistically significant;③ In terms of claudication distance,there was no significant difference in claudication distance between groups before treatment.After 4 weeks of treatment,the limping distance in both groups was significantly improved compared with before treatment.The limping distance in the study group was(637.65±217.25)meters,and the limping distance in the control group was(518.39±180.28)meters.The limping distance in the study group was significantly better than that in the control group,and the difference was statistically significant.④In terms of single syndrome,the study group was significantly better than the control group in the improvement of coldness,weakness and heaviness,and there were significant differences,and the improvement of numbness was also better than that of the control group,and the difference was statistically significant.⑤ In terms of SF-36 scores,the SF-36 scores of the two groups after 4 weeks of treatment were higher than those before treatment,which was significantly different.There was no significant difference in the somatic pain scores in the study group compared with the control group,which was not statistically significant,and the rest of the SF-36 scores were significantly higher than those in the control group,and the difference was statistically significant.⑥In terms of serum inflammatory factors,serum IL-1β,hs-CRP and ESR levels decreased after treatment in the two groups compared with before treatment,and the differences were statistically significant.The levels of inflammatory factors in the two groups were comparable after treatment,and the difference was not statistically significant.Conclusion:Fuyang Xuanbi Decoction can significantly relieve the symptoms of intermittent claudication in patients,improve the coldness,numbness and other symptoms,and improve the efficacy in anti-inflammatory and analgesic aspects,but it is not significant,on the whole,the treatment effectively improves the quality of life of patients,the efficacy is continuous and stable,and it is worth promoting in clinical practice.