Relationship Between Nutritional Status And Infection Complications After Chemotherapy In Non-hodgkin Lymphoma Patients

Objective By analyzing the relationship between the occurrence of infection after chemotherapy and the nutritional status in non-Hodgkin lymphoma patients,we can improve the clinical awareness of the risk and protective factors of infection in these patients,and improve the prognosis ultimately.Methods This is a retrospective cohort study.We collected and sorted out relevant data of non-Hodgkin lymphoma patients who were admitted to the Department of Hematology,Jiaxing Second Hospital from 01 January 2015 to 31 December 2019.A total of 63 patients were selected according to the inclusion and exclusion criteria.The nutritional level of patients was assessed by the Nutrition Prognosis Index(PNI).We observed differences in clinical characteristics and nutritional profiles between infected and uninfected patients and analyzed post-chemotherapy infections in the high PNI and low PNI groups.We used the spss26.0 statistical software for data analysis and the Shapiro-Wilk test for the normality test.Measurement data were expressed by mean and standard deviation or median and quartile,and comparisons between groups were performed using t test or Wilcoxon rank sum test.Count data were expressed by case number and percentage.The Chi-square test was used to perform the inter group comparisons.Correlation analysis was performed using the Spearman Correlation Analysis.The Youden index and boundary value were calculated from the ROC curve analysis.Finally,a multivariate Logistic regression analysis and Kaplan-Meier curve analysis were performed.Results1.A total of 63 patients were included in this study,among which the infection rate after primary chemotherapy was 23.81%and 55.56%during the whole course of treatment.2.There were statistical differences in PNI values between non-Hodgkin lymphoma patients before and after chemotherapy(P<0.001).3.There were statistical differences in pre-treatment PNI levels between the infected group and without infection group after chemotherapy(P=0.037).4.There were statistical differences in post-treatment infection between the high PNI and the low PNI groups before chemotherapy in non-Hodgkin lymphoma patients(P=0.008).5.Patient age(P=0.042)and PNI values before the primary chemotherapy(P=0.043)were independent factors of post-chemotherapy infection in non-Hodgkin’s lymphoma patients.Conclusion Chemotherapy affects the nutritional status of patients with non-Hodgkin lymphoma,and the occurrence of infections after chemotherapy is closely related to their nutritional status.Non-Hodgkin lymphoma patients with poor nutritional status should be identified early and given adequate nutritional support to reduce the incidence of infection and improve the prognosis.