To Explore The Effect Of Compound Sophora Flavescens Injection On Radiotherapy And Chemotherapy In Patients With Locally Advanced Non-small Cell Lung Cancer And Its AdverseReactions

Objective:The incidence rate of lung cancer is high and it is not easy to be detected.For locally advanced non-small cell lung cancer without surgical indications,the comprehensive treatment of sequential immunity followed by concurrent chemoradiotherapy is generally used in clinical practice.This study mainly observed the effect of compound sophora flavescens injection on the effective rate of disease treatment and the incidence of adverse reaction radiation lung injury and bone marrow suppression in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy.Methods:A selected 90 patients with stage III non-small cell lung cancer who were initially diagnosed and treated at Jining First People’s Hospital from October 2020 to December 2022,and randomly divided into two groups for different treatments:Group I(experimental group):45 patients were treated with combination of compound sophora flavescens injection during synchronous radiotherapy and chemotherapy,and sequential immunotherapy was performed on some patients who did not progress after synchronous radiotherapy and chemotherapy;Group II(control group):45 patients underwent synchronous radiotherapy and chemotherapy,and sequential immunotherapy was performed on some patients who did not progress after synchronous radiotherapy and chemotherapy.After the completion of synchronous radiotherapy and chemotherapy treatment,the treatment efficiency,quality of life improvement,radiation lung injury,bone marrow suppression,and immune suppression(changes in peripheral blood T cell subsets)of the two groups of patients were statistically analyzed.Results:The effective rate of treatment in the experimental group A was 62.22%,while the effective rate in the control group was 53.33%.There was no statistically significant difference in the effective rate between the two groups(P>0.05).The effective improvement rate of quality of life in the experimental group patients after treatment was62.22%,while the improvement rate of quality of life in the control group patients after treatment was 40.00%.There was a significant difference in the effective improvement rate of quality of life between the two groups,with statistical significance(P<0.05).The incidence of radiation induced lung injury in the experimental group was 17.78%after treatment,while the incidence of radiation induced lung injury in the control group was37.78%.There was a significant difference in the incidence of radiation induced lung injury between the two groups,with statistical significance(P<0.05).The incidence of bone marrow suppression after treatment in the experimental group was 28.89%,while the incidence of bone marrow suppression in the control group was 51.11%.There was a significant difference in the incidence of bone marrow suppression between the two groups,with statistical significance(P<0.05).Statistical analysis was conducted on the peripheral blood T cell subpopulations of two groups of patients before and after treatment.It was found that the CD4~+and CD4~+/CD8~+levels in the experimental group increased significantly after treatment,while the CD8~+levels decreased significantly after treatment(P<0.05).The CD4~+and CD4~+/CD8~+levels in the control group decreased significantly after treatment,and the CD8~+levels increased significantly after treatment(P<0.05).After treatment,the CD4~+and CD4~+/CD8~+levels in the experimental group were significantly higher than those in the control group,while the CD8~+levels were significantly lower than those in the control group,The difference was statistically significant(P<0.05).Conclusion:The combination of concurrent radiotherapy and chemotherapy for locally advanced non-small cell lung cancer with compound sophora flavescens injection shows an improvement trend in the treatment effectiveness rate,and can improve the patient’s immune function,improve their quality of life,and reduce the incidence of radiation induced lung injury and bone marrow suppression caused by radiotherapy and chemotherapy.