| Objective:In this study,patients with hepatorenal deficiency Parkinson’s disease complicated with sleep disorders were clinically collected,their gender,age and education level were collected,and scores of UPDRS,PSQI,ISI and TCM syndrome scale before and after treatment were recorded.The clinical data were analyzed before and after the treatment to observe the clinical effect of tonifying liver and kidney in the treatment of Parkinson’s disease with deficiency of liver and kidney combined with sleep disorder,so as to provide data for the traditional Chinese medicine treatment of Parkinson’s disease combined with sleep disorder.Methods:A total of 81 patients with Parkinson’s disease of liver and kidney deficiency combined with sleep disorder who met the inclusion criteria in the Department of Encephalopathy,Xiyuan Hospital,China Academy of Chinese Medical Sciences from November 2017 to November 2019 were collected and divided into control group and treatment group by random number table method,with 40 cases in the treatment group and 41 cases in the control group.The control group was given basic treatment with anti-Parkinson’s drugs,and the treatment group was given the prescription of tonifying liver and kidney based on the control group.The administration cycle of both groups was 12 weeks.UPDRS,PSQI,ISI and TCM Symptom Scale scores were performed before enrollment and 4,8 and 12 weeks after treatment.SPSS22.0 statistical software was used for statistical analysis.In the process of data analysis,the count data were described by frequency(N)and percentage(%),and the comparison of count data(such as age distribution,gender,disease grade,etc.)was tested by phi-square best.Mean ± standard deviation(’x±s)was used to describe the normally distributed data,and two independent samples T-test was used for comparison.Data disobedient to normal distribution were described by median and quartile spacing,and compared by Wilcoxon rank sum test of two independent samples.For intra-group comparison,paired T-test was used for data meeting normal distribution,while paired non-parametric test was used for data not meeting normal distribution.In this study,P<0.05 indicates statistical significance,P<0.01 indicates significant difference,and P>0.05 indicates no statistical difference between the two groups.Results:1.Eighty-one patients with Parkinson’s disease complicated with sleep disorders were collected in this study.Before treatment,there were no significant differences in age distribution,gender,disease grade and other aspects,and the clinical data were comparable.2.The UPDRS scale was evaluated in the two groups.The scores of UPDRS Ⅰ,UPDRⅡ and UPDRSⅢ in the observation group were significantly decreased after 4,8 and 12 weeks of medication,and the differences were extremely significant(P<0.01).In the control group,the scores of UPDRS Ⅰ,UPDRⅡ,UPDRSⅢ were significantly lower than those before and after treatment for 4 weeks(P<0.01).after 8 weeks of treatment,the scores of PDRS Ⅰ,UPDRⅡ were significantly lower than those after 4 weeks of treatment,but there was no significant difference.The UPDRSⅢ score was significantly decreased(P<0.01).The scores of UPDRS Ⅰ,UPDRⅡ and UPDRSⅢ after 12 weeks were significantly lower than those before medication(P<0.01).but there was no significant difference in the scores of UPDRⅡand UPDRSⅢ after 8 weeks of medication.3.In this study,the UPDRS scale was evaluated between the two groups.After 4 and 8 weeks of medication,the scores of UPDRS Ⅰ,UPDRⅡ and UPDRSⅢ in the observation group were significantly higher than those in the control group,and the differences were not statistically significant.After 12 weeks of medication,the scores of UPDRS Ⅰ and UPDRS Ⅱ in the observation group were significantly lower than those in the control group(P<0.01).While the scores of UPDRSⅢ in the observation group were significantly higher than those in the control group,and the differences were not statistically significant.4.The LED in the treatment group did not change significantly at 4 weeks and 8 weeks and 12 weeks after taking the drug,but the LED in the control group increased significantly at 4 weeks and 12 weeks after taking the drug,the difference was significant(P<0.05).Compared with the treatment group,the LED level in the control group increased significantly at 4 weeks,8 weeks and 12 weeks after medication,and the difference was significant(P<0.05).5.The PSQI scale score of the observation group was significantly decreased after 4,8 and 12 weeks of medication,and the difference was extremely significant(P<0.01).while the PSQI scale score of the control group was not significantly different after 8 and 12 weeks of medication,but it was significantly decreased after the first diagnosis,and the difference was extremely significant(P<0.01).Compared with the control group,the PSQI score of the observation group was significantly decreased at 8 weeks and 12 weeks after medication,and the difference was extremely significant(P<0.01)6.ISI scores in the observation group and the control group were significantly lower than before at 4,8 and 12 weeks after medication,and the differences in the groups were extremely significant P<0.01).Compared with the control group,the scores of ISI scale in the observation group were significantly decreased at 8 weeks and 12 weeks after medication,and the difference between the two groups was extremely significant(P<0.01).7.The scores of TCM syndrome scale in the observation group were significantly decreased at 4,8 and 12 weeks after medication,and the differences were extremely significant(P<0.01).The score of the control group was significantly lower at 4 weeks and 8 weeks than before(P<0.01).while the score of the 12 weeks was significantly higher than that of the 8 weeks but it was significantly lower than that of the first diagnosis(P<0.01)Compared with the control group,the score of TCM syndrome scale in the observation group was higher than that in the control group after 4 weeks of medication(P<0.01).8.After treatment,the observation group and the control group were evaluated and analyzed.Forty patients in the observation group were cured,of which 6 cases were cured,accounting for 15%.16 cases(40%)were effective.Effective 11 people,accounting for 27.5%;5 cases(12.5%)were improved.Two cases were ineffective,accounting for 5%,and the total effective rate was 80%.In the treatment group,there were 41 patients,of whom 2 were cured,accounting for 4.8%.9 cases(21%)had significant effect.Effective 10 people,accounting for 24%;13 cases(31.7%)were improved.7 cases were ineffective,accounting for 17%,and the total effective rate was 51.22%.The total effective rate of the two groups was significantly higher in the observation group than in the control group.Conclusion:The therapeutic effect of tonifying liver and kidney in the treatment of Parkinson’s disease combined with sleep disorders is significant,and it shows advantages in improving the mental,behavioral and emotional symptoms of Parkinson’s disease and activities of daily living,and can also improve the clinical symptoms of Parkinson’s disease sleep disorders. |
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