Study On The Correlation Between Myopia Progression And TCM Constitution In Children And Adolescents

Study 1 Meta-analysis of correlation between myopia and TCM constitution in children and adolescents.Objective:It is aiming to study the distribution of TCM constitution in children and adolescents with myopia,to explore the correlation between myopia and TCM constitution in children and adolescents,providing theoretical basis for TCM to prevent and control myopia.Methods:The Chinese and English databases of clinical studies on the TCM constitution and myopia in children and adolescents have been searched comprehensively.The search time is from the establishment of the databases to February 15,2023.After extraction of the included studies’ primary information,evaluated their methodological quality.Data analysis was finished by Stata 16.0 software,effect values were expressed by rate and 95%CI.Results:A total of 6 studies were included,of which 2 were cross-sectional studies and the other 4 were case-control studies.Among 8,165 case of myopic children and adolescents,normal-constitution accounted for 43%.The main types of lopsidedconstitution were qi-deficiency constitution(15%)and yin-deficiency constitution(11%).According to the results of the methodological quality evaluation,4 Casecontrol studies were of relatively medium quality and 2 cross-sectional studies were of low quality,resulting in a certain risk of bias.Conclusion:The lopsided-constitution(qi-deficiency constitution,yin-deficiency constitution)is the main TCM constitution of children and adolescents with myopia.Due to the influence of the quantity,quality and sample size of the included studies,the above results may have some deviations and need to be further studied.Study2 Clinical study on the ccorrelation between myopia progression and TCM constitution in children and adolescents.Objective:It is aiming to study the distribution of TCM constitution of children and adolescents with myopia and the correlation between the progression of myopia and TCM constitution,to analyze the relationship between TCM constitution and accommodation parameters(amplitude of accommodation,facility of accommodation)in myopic children and adolescents,so as to provide theoretical basis for the myopia prevention and control in TCM.Methods:From March 2022 to August 2022,8-12 years old patients with mild myopia were selected from the Ophthalmology Hospital of China Academy of Chinese Medical Sciences.The TCM constitution types were determined by the TCM constitution scale for people aged 7-14,which was developed by professor Wang Qi and his team.After the patients were enrolled,they were divided into the normal-constitution and lopsidedconstitution groups according their TCM constitution.The parameters of the eyes were measured,including axial length,spherical equivalent,corneal curvature,amplitude of accommodation and facility of accommodation,and to conduct health education in both of groups.After 3 months,the above mentioned parameters were re-examined,and the progression of myopia was analyzed in both normal-constitution and lopsidedconstitution groups.Results:1.A total of 193 cases of myopia are included in this study.The distribution of TCM constitution is as follows:lopsided-constitution(57.51%),normal-constitution(42.49%).The main lopsided-constitution types of the patients are yin-deficiency constitution(16.58%)and qi-deficiency(10.88%),then qi-stagnation(9.85%),yangdeficiency(7.77%),idiopathic constitution(4.66%),dampness-heat constitution(3.63%),phlegm-dampness constitution(2.07%),blood stasis constitution(2.07%).2.There is no significant difference in amplitude of accommodation and facility of accommodation between normal-constitution group and lopsided-constitution group(P>0.05).3.There are significant differences in axial length and spherical equivalent between the myopic children and adolescents in the normal-constitution group and the lopsidedconstitution group after self-observation(P<0.05).4.After 3 months of observation,the difference of axial length,spherical equivalent and corneal curvature of the myopic patients between the normal-constitution group and the lopsided-constitution group have no statistical significance(P>0.05).After 3 months,the difference of axial length difference and spherical equivalent difference between the normal-constitution group and the lopsided-constitution group are statistically significant(P<0.05).Conclusions:1.The distribution of TCM constitution of myopic children and adolescents is as follows:the patients with lopsided-constitution is more than those with normalconstitution,and the main lopsided-constitution types of children and adolescents with myopia are yin-deficiency constitution and qi-deficiency constitution.2.There is no difference in amplitude of accommodation and facility of accommodation between normal-constitution and lopsided-constitution myopic children and adolescents.3.The myopia progression of children and adolescents with lopsided-constitution is more quickly than those with normal-constitution.