Application Of IVIM Technology In Myocardial Microcirculation In Hypertensive Patients

Objective:To conduct IVIM sequence scanning on both healthy volunteers and hypertensive patients,aiming to investigate whether the IVIM sequence can effectively assess disparities in myocardial microcirculation perfusion between healthy individuals and those with hypertension,as well as among different hypertension severity levels.The study aims to explore the feasibility and clinical significance of utilizing the IVIM sequence in evaluating myocardial microcirculation perfusion.Materials and Methods:We collected a total of 102 subjects who underwent cardiac magnetic resonance examination at the imaging department of Shandong Provincial Hospital from December 2020 to September 2022.The scans were conducted using a Philips Ingenia 3.0T superconducting magnetic resonance system,which included both conventional anatomical structure sequences and IVIM sequences.Among the subjects,13 were included in the failure group due to poor image quality in the IVIM sequence,failing to meet the experimental requirements.The success group comprised 89 subjects whose images met the quality requirements.Out of these 89 subjects,62 met the diagnostic criteria for hypertension,while 27 did not have hypertension.Among the hypertensive individuals,we further divided the 62 subjects into three groups based on the severity of hypertension:Grade 1 hypertension group(H1 group),Grade 2 hypertension group(H2 group),and Grade 3 hypertension group(H3 group).After obtaining the images,the CMR movie sequence was imported into CVI42 software to extract ventricular morphological and structural parameters,such as ray fraction and maximum wall thickness peak value.Additionally,the IVIM sequence was imported into MR IMAgenGINE software to obtain microcirculation perfusion parameters:D*,D,and f.Statistical analysis of all the collected data was performed using SPSS26.0 software package.We analyzed and studied the basic information of the failure group and the success group,as well as the parameters between the normal healthy group and the hypertension subgroup.A significance level of P<0.05 was used to determine statistical differences.Results:(1)D*value(39.14±2.20)um2/ms in H1 group was significantly lower than that in normal healthy group(43.87±2.18)um2/ms,P=0.000<0.05,the difference was statistically significant;The D*value(3 1.86±3.49)um2/ms in H2 group was significantly lower than that in H1 group(39.14±2.20)um2/ms,P=0.000<0.05,the difference was statistically significant;The D*valuc of H3 group(24.68±5.31)um2/ms was significantly lower than that of H2 group(31.86±3.49)um2/ms,P=0.000<0.05,the difference was statistically significant.There was no significant difference in D value and f value between normal healthy group and hypertensive subgroups(P>0.05).(2)The peak value of maximum wall thickness,LVMS/BSA,LVMD/BSA in patients with hypertension were significantly higher than those in normal healthy people,and the difference was statistically significant(P<0.05);There was no significant difference in LVEF,LVCI,LVEDV/BSA,LVESV/BSA and other cardiac function parameters between hypertensive patients and normal healthy people(P>0.05).(3)The heart rate in the failure group was(11)times/minute,which was significantly different from that in the success group(11)times/minute,P=0.000.Conclusion:1.The IVIM sequence shows good feasibility for evaluating myocardial microcirculation perfusion.The parameter D*has a more valuable reference value for assessing myocardial microcirculation perfusion function compared to D and f,offering clinical value for completely non-invasive evaluation of abnormal myocardial microcirculation perfusion function.2.Myocardial microcirculation perfusion function in the hypertensive population exhibited a significant decrease compared to the normal healthy population.3.Hypertensive individuals displayed significantly higher peak values of maximum wall thickness and myocardial mass compared to normal healthy individuals.4.The heart rate of the examinee is one of the important factors that affect the image quality of IVIM sequence.