Correlation Between The Aggregate Index Of Systemic Inflammation And Severity And Prognosis Of Coronary Artery Disease

BackgroudCoronary atherosclerotic heart disease,is one of the common cardiovascular disease.The pathological basis of coronary atherosclerotic heart disease is Atherosclerosis(AS),which is thought to be a chronic inflammatory disease.The role of single inflammatory cells,such as monocytes and lymphocytes,in atherosclerosis has been much studied.In recent years,scholars have actively explored combining various inflammatory cells as a comprehensive indicator to evaluate the inflammatory state of the body.Many studies have been conducted on neutrophil lymphocyte ratio,platelet lymphocyte ratio and other similar indicators in cardiovascular diseases.The Aggregate Index of Systemic Inflammation(AISI)is a recently proposed comprehensive index,which has not been studied in the field of coronary heart disease.Therefore,this study designed a retrospective study to investigate its relationship with coronary heart disease and its clinical application value.ObjectivesThe purpose of this study was to investigate whether AISI is different between coronary heart disease and non-coronary heart disease,whether AISI is an independent risk factor for coronary heart disease,and whether it is correlated with the severity and prognosis of coronary heart disease.MethodsThis retrospective study included 1165 patients who accepted coronary angiography for the first time in Guangzhou First People’s Hospital,Zhongshan People’s Hospital and Nanfang Hospital from August 2017 to April 2022,and were split into non-CAD group(n=275)and CAD group(n=890).Follow-up was conducted on CAD group.Differences in baseline characteristics and AISI were analyzed between the two groups.Patients were divided into two groups according to the median AISI to investigate the relationship between AISI and the severity,clinical stability and prognosis of coronary heart disease.Results1.An independent risk factor for CAD was AISI(P<0.001);2.ROC curve was drawn to show that AISI predicted CAD area under the curve was 0.686(95%CI0.649-0.723),the best cut-off value was 234.2,and its sensitivity and specificity were 78.7%and 48.7%.The area under the curve of the prediction ACS was 0.700(95%CI0.669-0.731),the best cut-off value was 387.67,the sensitivity was 54%,and the specificity was 77.1%.3.High AISI was a risk factor for clinical instability of coronary heart disease,and the proportion of ACS in high AISI group was higher,with statistical significance(P<0.001);4.AISI was positively correlated with Syntax Score of CAD patients,r=0.22(P<0.001);5.ROC curve was drawn to show that the area under the curve of the high-risk group in AISI predicted Syntax score was 0.581(95%CI0.5410.621),the best cut-off value was 361.07,and the sensitivity and specificity were 62.9%and 53.2%;6.AISI was an independent risk factor for major cardiovascular adverse events(MACE)in patients with coronary heart disease(P<0.001);7.The ROC curve showed that the area under the curve predicted by AISI was 0.569(95%CI0.519-0.618),the best cut-off value was 589.42,and the sensitivity and specificity were 40.9%and 71.7%(P<0.05).Conclusion1.Compared with non-CAD patients,AISI level in CAD patients was higher;2.AISI was an independent risk factor for CAD,which was correlated with the severity and clinical stability of CAD.3.AISI was an independent risk factor for MACE in CAD patients,and the higher the AISI level,the greater the risk of Major Adverse Cardiovascular Event.