| Objective:To investigate the efficacy of catgut embedding therapy in the Front-Mu,Lower He-sea and Back-Shu points on functional dyspepsia(FD)with hepatogastric disharmony through general symptom scale,Traditional Chinese Medicine(TCM)Efficacy Evaluation Scale,Functional Dyspepsia Daily Quality of Life Scale(FDDQL)as well as Braingut peptide in serum to comprehensively evaluate its clinical application and explore its possible mechanism of function,so as to provide a scientific basis for the treatment of functional dyspepsia with Hepatogastric disharmony through the use of catgut embedding therapy in the Front-Mu,Lower He-sea and Back-Shu points.Methods:Patients diagnosed with FD in the Acupuncture and Moxibustion Department and Spleen and Gastroenterology of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine between November 2021 and November 2022 were screened.The principle of informed consensus was scrupulously complied with and 66 patients were sorted randomly into the treatment group and the control group in equal according to the election criteria.Both groups were treated with Front-Mu points LR14,CV12,Lower He-sea points GB34,ST36 and Back-Shu points BL18,BL21.The control group which is the acupuncture group was prescribed conventional acupuncture,5 out of 1 week,for a total of 4 weeks;As for the treatment group which is the catgut embedding group,the acupuncture points were buried once a week for 4 weeks.In this review,the TCM general Symptom Score Scale,the Chinese Medicine Evidence-based Efficacy Evaluation Scale and the FDDQL were utilized to assess the changes in patients’clinical symptoms and quality of life.Meanwhile the changes in serum motilin(MTL),5hydroxytryptamine 3(5-HT3)and 5-hydroxytryptamine 4(5-HT4)levels in the two groups before and after treatment were also measured by enzyme-linked immunoassay.The clinical therapeutic efficiency of the two groups was measured by the Nimodipine formular using the TCM Efficacy Evaluation Scale.The questionnaire scores and serum parameters were subjected to statistical analysis by SPSS 26.0 to determine the clinical curative effect and the plausible mechanisms.Results:1.A total of 66 patients were involved in this study.6 cases were removed and excluded during the study for reasons such as further studies,business trips,and medication taken during the therapeutic period,and finally 60 patients completed the clinical trial,with 30 cases in each group.2.The comparison of general Symptom Scale scores:Within-group comparison:both groups scored lower after treatment than pre-treatment(P<0.05).Between-group comparison:the catgut embedding group scored lower than the acupuncture group after treatment(P<0.05).3.Comparison of TCM Efficacy Evaluation Scale scores:①Comparison within total groups:after therapy,the total scores of patients in both groups were lower than pre-treatment(P<0.05);comparison between total groups:after therapy,the catgut embedding group scored lower than the acupuncture group after treatment(P<0.05).②Comparison within subgroups:After therapy,the sub-item scores of patients in both groups decreased compared with those before therapy(P<0.05);comparison within subgroups:after therapy,there was no significant difference between the two groups in the scores of "distension or discomfort in the stomach","irritability","belching"(P<0.05),while the differences in the scores of "distension and fullness","sighing" and "fatigued" were not statistically significant(P>0.05).4.Comparison of FDDQL scale scores:within-group comparison:FDQOL scores were elevated in both groups after treatment compared to pretreatment(P<0.05);between-group comparison:scores were better in the catgut embedding group than that in the acupuncture group at post-treatment(P<0.05).5.Comparison of serum brain-gut peptides:①Serum MTL:Within-group comparison:serum MTL levels improved in both groups after treatment compared to pre-treatment(P<0.05);between-group comparison:no statistically significant difference in serum MTL levels between the two groups after therapy(P>0.05).②Serum 5-HT3:within-group comparison:serum 5-HT3 levels were higher in both groups after treatment compared to pre-treatment(P<0.05);between-group comparison:serum 5-HT3 levels were higher in the catgut embedding group than that in the acupuncture group after treatment(P<0.05).③Serum 5-HT4:within-group comparison:serum 5HT4 levels were higher in both groups after treatment compared to pretreatment(P<0.05);between-group comparison:serum 5-HT4 levels were higher in the catgut embedding group than that in the acupuncture group after treatment(P<0.05).Conclusion:Both catgut embedding and conventional acupuncture can ameliorate the clinical symptoms of patients with FD with hepatogastric disharmony.Catgut embedding therapy has been shown to improve the symptoms of "gastric distension or discomfort","irritability" and "belching and acid reflux" in FD patients superior than that of conventional acupuncture,and the mechanism of this may be attributed to the elevation of serum MTL,5-HT3 and 5-HT4 levels.The clinical efficacy of catgut embedding therapy and its effect on the regulation of serum MTL,5-HT3 and 5-HT4 levels are superior to that of conventional acupuncture therapy,which therefore deserves clinical promotion. |
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