Clinical Effects Of Probiotic-enhanced Early Enteral Nutrition In Patients With Sepsis

Objective Exploring the clinical effects of enteral nutrition with probiotics(Bifidobacterium trisporus)in sepsis patients at early admission.Methods The study’s 90 sepsis patients were split into groups A and B.With 45 cases in each group,Group A received standard care,i.e.,the control group;Group B received standard care with Bifidobacterium trisporus adjuvant therapy,i.e.,the experimental group.To observe and compare the general baseline data before treatment;to compare the four inflammatory indexes of C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)before and after treatment in the two groups;to compare the four liver function indexes of direct bilirubin(DBIL),total bilirubin(TBIL),aspartate transaminase(AST)and alanine amino transferase(ALT)before and after treatment in the two groups;Three protein indexes: serum total protein(TP),albumin(ALB),and hemoglobin(Hb);two respiratory function indexes: duration of mechanical ventilation and prevalence of ventilator-associated pneumonia(VAP);three immune indexes: immunoglobulin Ig A,Ig G,and Ig M;and the occurrence of gastrointestinal adverse reactions.The therapeutic impact of probiotics on sepsis patients was summed up by examining the changes in the aforementioned parameters.Results 1.General baseline data for the patients in both groups,including age,gender,the distribution of primary infection lesions,underlying disease,APACHE II score,and SOFA score,did not demonstrate statistically significant differences(P>0.05).2.The drop in the experimental group was marginally bigger than the decline in the control group,and the difference was statistically significant.Patients’ liver function indexes and inflammatory indexes also revealed a decreasing tendency after therapy compared to the commencement of treatment(P<0.05).3.The experimental group’s patients experienced mechanical ventilation for a shorter period of time and experienced a lower incidence of VAP,with the difference being statistically significant(P<0.05).4.Patients in both groups saw varying degrees of decreases in serum protein levels as compared to before therapy,but there was no statistically significant difference in the size of these declines(P>0.05).5.Patients’ immunoglobulin levels in both groups exhibited an upward trend following treatment compared to the start of therapy;however,the experimental group’s increase was marginally bigger than the control group’s increase,and the difference was statistically significant(P<0.05).6.Patients in both groups of the study experienced gastrointestinal side effects during the course of the treatment;among these,the incidence of diarrhea,gastric retention,and constipation were compared,and the difference was statistically significant(P<0.05);the incidence of gastroesophageal reflux was compared,but the difference was not statistically significant(P>0.05).Conclusions Early enteral nutrition with probiotics(Bifidobacterium trisporus)has positive therapeutic effects on patients with sepsis,relieving their inflammatory response,regulating the immune system,alleviating functional impairment of the gastrointestinal tract,improving their liver function and respiratory function,and providing a degree of protection,which is worth promoting clinically as an adjunct to sepsis treatment.