| Objective: By collecting basic information,tumor markers and TCM constitution data of CTD-ILD patients,analyzing and describing the distribution characteristics of TCM constitution types of CTD-ILD,and analyzing the correlation between the constitution type and tumor markers of CTD-ILD patients.Methods: CTD-ILD patients who went to the Department of Respiratory and Critical Care Medicine of The Affiliated Hospital of Shandong University from December 2021 to December 2022 were collected,and 104 CTD-ILD patients were selected through inclusion and exclusion criteria.Fill in the TCM constitution questionnaire,detect tumor markers,evaluate the susceptible constitution types of CTD-ILD,analyze the correlation between tumor markers and constitution types,and draw conclusions.Results:1.The proportion of CTD-ILD patients meeting the inclusion criteria of this study was nearly 1:1,among which48.91% were male and 51.09% were female,mean age(65.03± 10.82),nearly normal distribution,29-59 patients,59-69.78%,high incidence rate,which was statistically significant compared with the remaining two groups(P <0.05).2.Physical distribution of CTD-ILD patients in this study: Qi deficiency accounted for 10.5%,qi depression 18.9%,humid heat 11.6%,sputum dampness 14.7%,blood stasis27.4%,Yang deficiency 9.5%,and Yin deficiency 4.2%.Blood stasis,phlegm-dampness,and qi depression were the most common diseases of CTD-ILD,which were significantly different from the remaining four groups(P <0.05).3.In this study,there was no significant correlation between age and constitution in CTD-ILD patients(P> 0.05),and no significant correlation between sex and constitution in CTD-ILD patients(P> 0.05).4.In this study,no significant correlation between age and tumor markers in CTD-ILD patients(P> 0.05),and no significant correlation between sex and tumor markers in CTD-ILD patients(P> 0.05).5.In this study,the embryonic antigen levels of blood stasis,phlegm and dampness,dampness-heat and qi deficiency were significantly higher than normal.The level of CA199 in qi stasis,blood stasis,phlegm dampness and humid heat were significantly higher compared with the highest normal value.The level of antigen associated with blood stasis squamous cell carcinoma was significantly increased compared with the normal maximum.The levels of cytokeratin 19 fragments of qi depression,damp heat and Yin deficiency were significantly higher compared with the highest normal values.6.The area under the ROC curve of CTD-ILD patients was between 0.5-1(0.522),CA724(0.735),CA199(0.591),squamous cell carcinoma-associated antigen(0.563),cytokeratin 19 fragment(0.570),It suggests that alpha-fetoprotein,CA724,CA199,squamous cell carcinoma-related antigen,and cytokeratin 19 fragments are promising as indicators to distinguish the constitution type of TCM,Index between 0.7-1 is CA724(0.701),It suggests that it is the most valuable indicator to identify the TCM constitution type of CTD-ILD.Conclusion:1 The male to female ratio of CTD-ILD patients in this study was close,and the age group with a high incidence of patients was 40 – 79 years.2.Changes in tumor markers in CTD-ILD patients in this study were not found to be related with gender or age.3.In this study,it was found that blood stasis,sputum dampness,and qi depression were the most common diseases of CTD-ILD.4.In this study,it was found that carcinoembryonic antigen may become the judgment index of blood stasis,phlegm dampness,dampness and heat,and qi deficiency.CA199 may become the judgment index of qi stasis,blood stasis,phlegm dampness,and humid heat.The antigen level associated with squamous cell carcinoma may be an indicator of blood stasis quality.Cytokeratin 19 fragment may be an indicator of qi depression,damp heat and Yin deficiency.5 In this study,it was found that the tumor marker CA724 is useful for the discrimination of gas-stasis CTD-ILD. |
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