Analysis Of The Relationship Between Tic Disorder And Cellular Immunity In Children

ObjectiveBy analyzing the etiology of cellular immunity in children with tic disorder(TD)and its correlation with psychosocial factors,to preliminarily explore the role and mechanism of cellular immunity in the pathogenesis of TD,and to study the impact of family environment,anxiety and depression on TD.effects in children,providing guidance for clinical interventions.MethodsA total of 62 TD children who visited the pediatric outpatient clinic from January 2019 to October 2020 were selected as the research subjects.According to the second part of the Yale Tic Global Severity Scale(YGTSS),32 cases were in the mild group and 30 cases in the moderate-severe group;During the same period,30 healthy children were taken as the control group.The levels of T lymphocytes,serum specific immunoglobulin E(s Ig E),total immunoglobulin E(TIg E),vitamin A(Vit A)and vitamin D(Vit D)in children were detected.The correlation between serum TIg E,s Ig E,Vit A,Vit D levels and YGTSS score was analyzed.The TD children were treated with vitamin AD drops combined with comprehensive intervention for12 weeks,and the changes of YGTSS scores before and after treatment were compared.Results1.There were significant differences in CD4+,CD4+/CD8+ cells between the control group and the TD subgroups(P<0.05).There was no significant difference in CD3+,CD8+ and NK cells between the control group and the TD subgroups(P>0.05).Pairwise comparison between groups: CD4+ cells in mild TD group and moderate-severe TD group were(28.15±3.07)% and(25.74±2.57)%,respectively,which were lower than those in the control group(30.59±3.59)%;mild TD The CD4+/CD8+ cells in the TD group and the moderate-severe TD group were(0.92±0.13)%,(0.84±0.09)%,which were lower than(1.02±0.15)% in the control group;CD4+,CD4+/CD8+ in the moderate-severe TD group The cells were lower than those in the mild TD group;the differences were statistically significant(P<0.05).There were significant differences in the positive rates of TIg E and s Ig E,and the levels of Vit A and Vit D among the groups(P<0.05).The positive rate of TIg E in the moderate and severe TD group was 86.67%,which was higher than that in the mild TD group(68.75%).Pairwise comparison between groups: the positive rate of s Ig E in the moderate-severe TD group was 80.00%,which was higher than33.33% in the mild TD group.Academic significance(P<0.05).The levels of Vit A and Vit D in the moderate-severe TD group were lower than those in the mild TD group and the control group.2.There was a statistically significant difference in ANA absorbance between the control group and the TD subgroups(P<0.05).Pairwise comparison between groups: ANA absorbance of children in mild TD group and moderate-severe TD group were(0.062±0.008)and(0.097±0.013),which were higher than those in the control group(0.043±0.006);ANA of children in moderate-severe TD group The absorbance was higher than that of the mild TD group;the difference was statistically significant(P<0.05).3.CD4+,CD4+/CD8+ and NA absorbance were negatively correlated(r=-0.528,-0.592,P<0.01),and CD4+ was positively correlated with CD4+/CD8+(r=0.528,P<0.01).There was no correlation among NK,CD3+,CD8+.Serum TIg E and s Ig E were positively correlated with YGTSS score(r=0.429,0.394,P=0.007,0.015);Vit A and Vit D levels were negatively correlated with YGTSS score(r=-0.406,-0.438,P=0.011,0.006).4.After treatment,the YGTSS scores of the mild TD group and the moderate to severe group were lower than those before treatment,the positive rates of Tlg E and s Ig E antibodies were lower than those before treatment,and the levels of Vit A and Vit D were higher than those before treatment,and the differences were statistically significant(P<0.05).Conclusions1.TD children have cellular immune dysfunction,and the level of autoantibodies(antinuclear antibodies)increases: the positive rates of serum TIg E and s Ig E in TD children are significantly increased,the levels of Vit A and Vit D are significantly decreased,and the levels of TIg E,s Ig E,and s Ig E The levels of Vit A and Vit D were correlated with the severity of the disease.2.Vitamin AD drops combined with comprehensive intervention in children with TD can achieve better results.