Correlation Analysis Between TNM Staging Of Non-Small Cell Lung Cancer And Tcm Syndromes,Coagulation And Inflammation Indexes

Objective: Through the collection of clinical data and peripheral blood test results of patients with non-small cell lung cancer and the discriminant analysis of TCM syndrome types,the relationship between TNM staging of non-small cell lung cancer and TCM syndrome types,coagulation and inflammatory indexes was discussed.It provides a basis for the evaluation and prognosis of patients with non-small cell lung cancer,and provides a reference for TCM syndrome differentiation and treatment.Methods: NSCLC patients from the Department of Oncology,Department of Thoracic Surgery and Department of Respiratory Medicine of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from December 2021 to December 2022 were selected.For patients who meet the inclusion and exclusion criteria,their basic data,pathological types,TNM staging,etc.were collected,and their blood routine and coagulation routine test results were collected.According to the clinical information collection table to determine the TCM syndrome type.Through the application and statistical analysis of SPSS 23.0 software and EXCEL tables,the relationship between TNM staging of non-small cell lung cancer and TCM syndrome types,coagulation and inflammatory indicators was discussed.Results:1.A total of 146 patients were collected,including 109 male patients and37 female patients.The proportions were 74.7 % and 25.3 %,respectively.The number of people is mainly distributed in the three intervals of 51-60 years old,61-70 years old,and 71-80 years old.The frequencies are 35 cases,49 cases,and 38 cases,respectively,accounting for 24 %,33.6 %,and 26 %,respectively.The mean age was 63.25 ± 11.51 years.2.TNM staging distribution : The TNM staging distribution of 146 NSCLC patients included in this study was : stage IV(52.7 %)> stage I(26.7 %)> stage III(14.4 %)> stage II(6.2 %).3.Distribution of TCM syndromes :(1)Among 146 patients with NSCLC,phlegm-dampness syndrome had the highest frequency,followed by qi deficiency syndrome,yin deficiency syndrome and blood stasis syndrome,with the constituent ratios of 29.38 %,25.12 %,18.48 % and 14.69 %,respectively.The proportion of other syndromes is relatively small.(2)The most TCM syndromes are empirical,a total of 80 cases;deficiency syndrome followed,a total of 44 cases;the syndrome of intermingled deficiency and excess was relatively less,a total of 17 cases;other(i.e.,undocumented)a total of 5 cases.The empirical evidence was mostly distributed in stage I and stage IV,with 27 cases and 31 cases respectively.The deficiency syndrome was mainly distributed in stage IV,with 32 cases;the syndrome of intermingled deficiency and excess was distributed in stage III and IV,especially in stage IV,with 14 cases.(3)The combination of syndrome types was the most single syndrome,73 cases,accounting for 50 %,of which 35 cases were phlegm-dampness syndrome,accounting for 47.9 %,followed by blood stasis syndrome,13 cases,accounting for 17.8 %.There were 66 cases of both syndromes,accounting for 45.21 %,of which 32 cases were ’ qi deficiency syndrome +yin deficiency syndrome ’,accounting for 48.5 %.There were 11 cases of ’ qi deficiency syndrome + phlegm dampness syndrome ’ and 10 cases of ’ phlegm dampness syndrome + blood stasis syndrome ’,accounting for 16.7 % and15.2 % respectively.There were only 2 cases of three or more syndromes,accounting for 1.37 %.4.The relationship between TNM staging and TCM syndromes in patients with non-small cell lung cancer : Qi deficiency syndrome,Yin deficiency syndrome and phlegm dampness syndrome were significantly different in different TNM stages(P < 0.01).There were significant differences in blood stasis syndrome in different TNM stages(P < 0.05).There were significant differences in TCM syndromes in different TNM stages(P < 0.01).5.The relationship between TNM stage and inflammatory markers in patients with non-small cell lung cancer : The levels of PLT,PLR,NLR and LMR were significantly different in different TNM stages(P < 0.01),and the levels of PLT,PLR and NLR were positively correlated with TNM stage.The level of LMR in stage III and IV patients was significantly lower than that in stage I and II patients.6.The relationship between TNM stage and coagulation index in patients with non-small cell lung cancer : D-D and FIB were significantly different in different TNM stages(P < 0.01),and D-D and FIB levels were positively correlated with TNM stage;there were significant differences in PT among different TNM stages(P < 0.05).The PT level of stage I-III had an upward trend,and there was statistical significance between stage IV and stage I(P <0.05).There was no significant difference in APTT between different TNM stages.Conclusion(s):1.Among the TCM syndromes of NSCLC,phlegm-dampness syndrome,qi deficiency syndrome,yin deficiency syndrome and blood stasis syndrome are the most common;among them,phlegm-dampness syndrome and blood stasis syndrome are the most common single syndromes,and ’ qi deficiency syndrome + yin deficiency syndrome ’ is the most common compound syndrome.Therefore,attention should be paid to resolving phlegm and removing blood stasis,replenishing qi and nourishing yin in treatment.2.There is a correlation between TNM staging and TCM syndromes in NSCLC patients.In stage I and II,phlegm-dampness syndrome,blood stasis syndrome and qi deficiency syndrome are more common,especially phlegm-dampness syndrome.Qi deficiency syndrome,phlegm dampness syndrome and yin deficiency syndrome were more common in stage III and IV,especially Qi deficiency syndrome.3.There was a correlation between TNM staging and inflammatory markers PLT,PLR,NLR and LMR in patients with non-small cell lung cancer.The later the TNM stage,the higher the levels of PLT,PLR and NLR.At the same time,the level of LMR in middle and late stage was significantly lower than that in early stage.It is suggested that PLT,PLR,NLR and LMR can be used as important reference indexes for the evaluation and prognosis of NSCLC patients.4.There is a correlation between TNM stage and coagulation indexes D-D,PT and FIB in patients with non-small cell lung cancer.The later the TNM stage is,the higher the levels of D-D and FIB are.Therefore,D-D and FIB can also be used as important indicators to evaluate the condition and prognosis of NSCLC patients.The level of PT has an upward trend in stage I-III,and stage IV is significantly higher than stage I,suggesting that PT may also be one of the indicators to evaluate the condition and prognosis.This study found that there is no correlation between APTT and TNM staging,and the correlation between the two needs to be demonstrated by more and larger sample size studies.