Analysis Of Wenbu School In Ming Dynasty Medication Experience In Treating Constipation Based On Data Mining

Objective:Based on the Data mining methodologies,the Traditional Chinese medicine inheritance computing platform system is used to mine the prescription and medication rules for constipation in the representative medical works of the Wenbu School,in order to reveal the prescription and medication rules of the Wenbu School for constipation treatment and guide clinical practice.Methods:Collect and sort out the relevant works of the representative physicians of the Wenbu School in the Ming Dynasty,manually retrieve and collect the data of the prescriptions and drugs used to treat constipation,normalize the information of the prescriptions and traditional Chinese medicine,establish the analysis database of the prescriptions and drugs of the doctors of the Wenbu School in the Ming Dynasty,and use the Traditional Chinese medicine inheritance computing platform system to carry out data mining on the characteristics,tastes,meridians,efficacy classification,association rules,clustering results of Traditional Chinese medicine.Results:Through searching,135 effective prescriptions were included,involving 170 traditional Chinese medicines.The cumulative frequency of drug use was 1176 times,36 drugs were used more than 10 times,and 9 high-frequency drugs were used.The frequency of occurrence from high to low was angelica sinensis(62 times),rhubarb(44 times),ginger(43 times),roasted licorice(42 times),poria cocos(41 times),cooked rehmannia(39 times),ginseng(38 times),licorice(36 times),and atractylodes macrocephala(36 times).The cumulative frequency of the four qi of traditional Chinese medicine was 1121 times,of which the highest was warm drugs(499 times),followed by cold drugs(366 times)and mild drugs(218 times).The cumulative frequency of the five flavors of traditional Chinese medicine is 1674 times,of which the highest is sweet drugs(593 times),followed by bitter drugs(562 times)and bitter drugs(383 times).Traditional Chinese medicine involves twelve meridians,with a cumulative frequency of 3370 times,the highest of which is spleen meridian(687 times),followed by lung meridian(492 times),stomach meridian(465 times),heart meridian(450 times),liver meridian(433 times),kidney meridian(305 times),and large intestine meridian(226 times).There are 19 categories of drug efficacy,with a cumulative frequency of 1121,of which the highest is 379 in the category of tonifying deficiency,followed by the category of clearing heat(151 times),the category of relieving external symptoms(109 times),the category of purgation(90 times),the category of Liqi(90 times),and the category of activating blood circulation and removing stasis(72 times).Under the condition of 15%support and 0.9 confidence,33 high-frequency drug combination data were obtained,in descending order of frequency:ginseng-atractylodes macrocephala(30 times),angelicarehmannia(29 times),atractylodes macrocephala-roasted licorice(28 times),ginseng-roasted licorice(27 times),atractylodes macrocephalaporia cocos(26 times),ginger-jujube(26 times),etc.Cluster analysis showed that there were 71 prescriptions with angelica,rhubarb,white peony,licorice and ginseng as the core drug group in the first category,44 prescriptions with poria cocos,roasted licorice,ginseng,prepared rehmannia and atractylodes macrocephala as the core drug group in the second category,and 20 prescriptions with fructus aurantii,rhubarb,licorice,angelica and hemp seed as the core drug group in the third category.Conclusion(s):Based on the Data Mining methodologies,this study uses the Traditional Chinese medicine inheritance computing platform system to carry out data mining on the medication of the Wenbu School to treat constipation on behalf of doctors,and preliminarily analyzes the medication rules of the Wenbu School to treat constipation,and draws the following conclusions:1.In the treatment of constipation by doctors of the Wen Bu school,sweet taste is often used to nourish deficiency,bitter taste is often used to relieve yin,and pungent taste is often used to regulate qi circulation;They are skilled in using methods such as strengthening the spleen,supplementing qi,nourishing yin,and nourishing blood to fill congestion,Not only for warming and tonifying,but also for using laxative and cooling drugs as appropriate.2.Clinical medication mainly uses sweet taste to nourish and nourish deficiency,bitter taste to relieve and strengthen yin,and spicy taste strips to smooth qi circulation.Medicines such as Angelica,Rheum,Rehmannia,Ginseng,and Atractylodes macrocephala,as well as traditional Chinese medicine decoctions such as Sijunzi Tang,Wufu Yin,Bazhen Tang,and Huanglong Tang,are often used by doctors of the Wenbu School to treat constipation..The theory and medication experience of the doctors of the Wenbu School in treating constipation have important guiding significance for the treatment of constipation in modern Chinese medicine,especially for the treatment of constipation with spleen and stomach weakness,qi and blood weakness,and deficiency and excess.