Study On The Differences Of TCM Syndrome Types And Related Factors Between Left- And Right-sided Colorectal Cancer

Objective: To observe the distribution of TCM syndrome types between leftand right-sided colorectal cancer,and investigate the correlation between leftand right-sided colorectal cancer and TCM syndrome types,gender,age,pathological type,differentiation degree,TNM stage,tumor marker level,inflammatory index level and blood lipid level.Material and method:This study is a retrospective study.The subjects of the study were 110 patients with colorectal cancer who met the inclusion criteria and were hospitalized in the First Affiliated Hospital of Guangxi Traditional Chinese Medicine University from January 2020 to December 2022.By collecting the patients’ medical record data,including the four diagnostic information of traditional Chinese medicine,gender,age,symptoms,site of disease,pathological type,degree of differentiation,TNM stage,tumor marker level(CEA,CA199,CA125),inflammatory index level(platelet-to-lymphocyte ratio(PLR),neutrophil-to-lymphocyte ratio(NLR),lymphocyte-to-monocyte ratio(LMR)and fibrinogen-to-prealbumin ratio(FPR)),Blood lipid level(triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)).Use the above information to set up a database,process and analyze all data with the help of statistical software,and observe the distribution of left-and right colorectal cancer and TCM syndrome types and the law between relevant factors.Results: A total of 110 patients with colon cancer were included in this study,including 65 males and 45 females,with a ratio of about 1.4:1.The age of the case in this study was between 27 and 86 years old,with the average age of(60.48 ± 14.30).(2)The distribution of left-sided colorectal cancer syndrome types: large intestine dampness-heat syndrome(41.82%)>accumulate knot poison and blood stasis syndrome(29.09%)> qi and blood deficiency syndrome(16.36%)>spleen and kidney deficiency syndrome(12.73%);Distribution of syndrome types of right-sided colorectal cancer: qi and blood deficiency syndrome(40%)> spleen and kidney deficiency syndrome(30.91%)> accumulate knot poison and blood stasis syndrome(18.18%)> large intestine dampness-heat syndrome(10.91%).The distribution of TCM syndrome types of left-and right-sided colorectal cancer is statistically significant(P<0.001).(3)There was no significant difference between the distribution of left-and right-sided colorectal cancer and gender,age,TNM stage,CEA,CA199,CA125,HDL-C,PLR,NLR,LMR,FPR(P>0.05).There were statistically significant differences between left-and right-sided colorectal cancer and pathological type,degree of differentiation,number of patients with abnormal CA199,distribution of TG,TC,LDL-C(P<0.05).(4)There was no significant difference between TCM syndrome type and gender,pathological type,differentiation degree and TNM stage distribution(P>0.05).In the ≤ 44 years old group and the 44-59 years old group,the patients with accumulate knot poison and blood stasis syndrome accounted for the largest proportion,40.00% and 34.62%respectively.In the group ≥ 60 years old,patients with qi and blood deficiency syndrome accounted for 39.06% of the total.There was statistically significant difference between TCM syndrome types and age distribution(P<0.05).(5)There was no significant difference between the distribution of TCM syndrome types and CEA,CA199,CA125,NLR and LMR(P>0.05).The distribution of PLR is the highest in the qi and blood deficiency syndrome and blood,and the rest from high to low is stasis and toxin accumulation syndrome>spleen and kidney deficiency syndrome> large intestine dampness-heat syndrome.The distribution of FPR is the highest in the syndrome of deficiency of both qi and blood,and the other from high to low is spleen and kidney deficiency syndrome> accumulate knot poison and blood stasis syndrome>large intestine damp-heat syndrome.The distribution of TCM syndrome types and PLR and FPR was statistically significant(P<0.05).(6)There was no significant difference between TCM syndrome type and TG,HDL-C distribution(P>0.05).The distribution of TCM syndrome types and TC is the highest in the accumulate knot poison and blood stasis syndrome,and the rest from high to low are large intestine dampness-heat syndrome,spleen and kidney deficiency syndrome,and qi and blood deficiency syndrome.The distribution of TCM syndrome types and LDL-C is the highest in accumulate knot poison and blood stasis syndrome,and the rest from high to low is large intestine dampness-heat syndrome,spleen and kidney deficiency syndrome,and qi and blood deficiency syndrome.The distribution difference between TCM syndrome type and TC,LDL-C was statistically significant(P<0.05).(7)Qi and blood deficiency syndrome was positively correlated with PLR and FPR levels,and negatively correlated with TC and LDL-C levels(P <0.05).There was a positive correlation between accumulate knot poison and blood stasis syndrome and TC level(P <0.05).Conclusion:(1)The left-sided colorectal cancer is mainly characterized by large intestine dampness-heat syndrome,followed by accumulate knot poison and blood stasis syndrome,qi and blood deficiency syndrome,spleen and kidney deficiency syndrome.The right-sided colorectal cancer is mainly characterized by qi and blood deficiency syndrome,followed by spleen and kidney deficiency syndrome,accumulate knot poison and blood stasis syndrome,and large intestine dampness-heat syndrome.(2)The left-and right-sided colorectal cancer are correlated with syndrome type,pathological type,differentiation degree,CA199,TG,TC,LDL-C.(3)TCM syndrome types of colorectal cancer are correlated with age,PLR,FPR,TC,LDL-C.(4)The syndrome of deficiency of qi and blood in colon cancer is positively correlated with the level of PLR and FPR,indicating that the higher the level of PLR and FPR,the greater the probability of syndrome differentiation of deficiency of qi and blood.The syndrome of deficiency of qi and blood is negatively correlated with the levels of TC and LDL-C,indicating that the greater the probability of syndrome differentiation of deficiency of qi and blood is with the decrease of the levels of TC and LDL-C.The syndrome of accumulate knot poison and blood stasis is positively correlated with the level of TC,indicating that the higher the level of TC,the greater the probability of syndrome differentiation of accumulate knot poison and blood stasis.