Clinical Observation Of Xuefu Zhuyu Decoction Combined With Blood Flow Restriction Training In The Treatment Of Knee Osteoarthritis Of Qi Stagnation And Blood Stasis Type

Objective: This study was divided into three groups: control group Ⅰ,control group Ⅱ and experimental group.Control group Ⅰ : oral celecoxib alone;control group Ⅱ : oral celecoxib combined with blood flow restriction training;experimental group: Oral Xuefu Zhuyu Decoction combined with blood flow restriction training treatment,the treatment objects were all patients with Knee osteoarthritis(KOA)of early Qi-stagnation and blood-stasis type.Through comparison between the three groups,the clinical significance of Xuefu Zhuyu decoction combined with blood flow restriction training therapy was explored,in order to optimize the treatment plan of KOA.To provide a more safe,effective and appropriate treatment method for clinical treatment of KOA patients,so as to improve the quality of life of patients.Study contents: Patients with KOA were selected as subjects.The selected cases were inpatients and outpatients in the first ward of Orthopaedic Trauma in Liuzhou Hospital of Traditional Chinese Medicine from March 1,2022 to August 31,2022.A total of 75 patients meeting the inclusion and exclusion criteria were included and divided by random number table method.25 patients took celeoxib orally as control group Ⅰ.25 patients with oral celecoxib combined with blood flow restriction training were control group Ⅱ;25 patients were treated with Xuefuzhuyu decoction combined with blood flow restriction training.Basic data of the patients were recorded,including gender,age,course of disease,VAS visual analogue pain scale(VAS score),Western Ontario and Mc Master University Osteoarthritis Index Visual Scale(WOMAC),knee extensor strength before treatment,7 and 21 days after treatment,and the results were statistically analyzed.Results:(1)General situation before treatment: comparison of gender,age and course of disease among the 3 groups.There was no statistical significance(P > 0.05),and there were no significant differences in VAS score,WOMAC score and standardized knee extensor muscle strength between the three groups(P>0.05),indicating that the three groups were comparable.(2)Efficacy indicators:(1)Comparison of WOMAC and VAS before and after treatment in the three groups,as shown in Table 1 and 2.Before treatment,there was no significant difference in WOMAC and VAS scores among the 3 groups,P>0.05.On the 7th and 21 st day of treatment,the WOMAC and VAS scores of the test group were lower than those of control group Ⅰ and control group Ⅱ,and the difference was statistically significant,P< 0.05.The WOMAC and VAS scores of the control group Ⅱ were also lower than those of the control group I,showing a statistically significant difference,with P<0.05.(2)Comparison of standardized extensor knee strength in three groups:before treatment and on the 7th day of treatment in control group I,control group II and test group,there was no significant difference(P>0.05),but on the 21 st day of treatment,there was no significant difference(P>0.05),the standardized extensor strength of the two groups was significantly higher than that of the control group I(P< 0.05),and there was no significant difference between the two groups(P>0.05).(3)Efficacy: In control group I,1 case was cured,6 cases were markedly effective,11 cases were effective and 7 cases were ineffective,while in Control Group II,2 cases were cured,8 cases were markedly effective,10 cases were effective and 5 cases were ineffective,and in test group,2 cases were cured,the total effective rate was 72% in the control group I,80% in the Control Group II,and 88% in the test group,the difference was significant(P<0.05).(4)Safety: A total of 2 adverse reactions occurred during the whole study.One patient in the experimental group had pain at the surface projection of the rectus femoris body,which could be relieved by itself after 1 day of observation,and no discomfort occurred after follow-up treatment.In control group Ⅱ,there was 1 case with mild dizziness and headache,which improved spontaneously after observation,and no serious adverse events occurred in the3 groups.Conclusion: Xuefu Zhuyu Decoction combined with blood flow restriction training in the treatment of early Qi-stagnation and blood-stasis type knee osteoarthritis has definite and satisfactory clinical efficacy and high safety.This therapy can effectively improve the patients’ knee range of motion,stretching knee muscle strength and relieve the symptoms of knee pain,and is worthy of clinical promotion.