Research On Data Mining Of Professor Lin Shouning’s Medication Rules For The Treatment Of Functional Constipation

Objective: This study takes Professor Lin Shouning’s prescription Chinese medicine for the treatment of functional constipation as the research object,and uses data mining methods to conduct retrospective analysis and research on it.The aim is to summarize the characteristics of Professor Lin Shouning’s treatment of functional constipation and the characteristics of Professor Lin Shouning’s treatment of functional constipation.The academic thoughts of the authors provide treatment ideas and references for clinicians in the treatment of functional constipation.Methods: A retrospective analysis and research were conducted on220 outpatient medical records and prescription Chinese medicines of Professor Lin Shouning from October 2019 to October 2020 for the treatment of 190 patients with functional constipation.Enter the patient’s general information,four-diagnosis information,TCM syndromes,and TCM drug names into the Excel table,and process the entered data,upload the processed data to the TCM inheritance calculation platform(V3.0)system,and enter The frequency statistics and basic drug information(four qi,five flavors,meridian)statistics of the traditional Chinese medicines used in 220 prescriptions;secondly,the number of support is set to 60%,the confidence is set to 0.9,and the group Analysis of prescription rules(drug mode,association rules);finally,the number of cluster analysis is set to 3,trying to dig out the hidden common combinations for the treatment of functional constipation,and form a new treatment method for the treatment of functional constipation.Finally,Professor Lin Shouning’s medication rules for the treatment of functional constipation are summarized.Results:(1)A total of 220 outpatient prescriptions were entered for190 patients,of which 81 were males and 109 were females.The most common were 50-59 years old(31.05%).(2)Six syndrome types were recorded in the included outpatient medical records.The syndrome types were Yin deficiency secretion(110times,50.00%),Qi deficiency secretion(53 times,24.09%),Qi stagnation secretion(27 times,12.27%).Heat accumulation secretion(16 times,7.27%),blood deficiency secretion(12 times,5.45%),Yang deficiency secretion(2 times,0.91%).(3)In the 220 outpatient prescriptions,the four Qi of traditional Chinese medicine was mostly cold medicine(39.42%),followed by warm and flat medicines.The five flavors of traditional Chinese medicine are mainly sweet drugs(42.66%),followed by bitter and pungent drugs.In general,the four qi and five flavors of traditional Chinese medicine are mainly cold and sweet medicines.Among them,the main meridians are the stomach meridian(1654 times),the spleen meridian(1614 times),the lung meridian(1552 times),and the large intestine meridian(885 times).(4)The 220 prescriptions included in this study involved 96 Chinese medicines,which belonged to 10 Chinese medicine categories.The cumulative frequency of medications reached 3,076.Among them,20 Chinese medicines appeared more than 50 times.The most frequently used are Licorice(203 times),Magnolia officinalis(199 times),Gualouzi(189 times),Gualou peel(186 times),Trifoliate(182 times),Astragalus(177 times),Hemp Ren(162 times).(5)Set the number of support to 60% and the confidence to 0.9 to obtain 85 commonly used drug modes,involving 7 core drugs,21 pairs of2 commonly used drug combinations,and 33 pairs of 3 commonly used drug combinations.Obtained 24 pairs of 4 commonly used drug combinations and 7 pairs of 5 commonly used drug combinations.Based on the 85 commonly used drug models,the prescription medication rules were studied,and finally 197 drug association rules with a confidence level of 0.90 or more were obtained.,There are 20 drug association rules with a confidence of 0.99.(6)Through the cluster analysis of the input 220 prescriptions,it is concluded that Professor Lin Shouning has 3 core combinations for the treatment of functional constipation and 3 potential drug combinations for the treatment of functional constipation.Conclusion(s): Professor Lin Shouning’s treatment of functional constipation emphasizes dialectical treatment and believes that deficient constipation is the most common constipation.There are 96 traditional Chinese medicines involved in the treatment of functional constipation.Among them,licorice,Magnolia officinalis,Gualouzi,Gualou peel,Citrus aurantium,Astragalus and Hemp seed are the most frequently used.The most commonly used drugs with 2,3,4,and 5 flavors are"licorice-magnolia","magnolia officinalis-Gualouzi-Gualoupi","magnolia officinalis-Fructus Aurantii-Gualouzi-gua" "Loupi","Glycyrrhiza-Magnolia officinalis-Gualouzi-Gualou peel-Citrus aurantium".According to the cluster analysis,three core combinations for the treatment of functional constipation by Professor Lin Shouning were obtained,namely "Licorice-Astragalus-Magnolia officinalis-Fructus Aurantii-Angelica","Licorice-Gualouzi-Magnolia officinalis-Gualou peel-Rehmannia glutinosa" ","Glycyrrhiza-Magnolia officinalis-Gualouzi-Gallus gallus domesticus-Chenpi".