The Relationship Between Fetal Famine Exposure And Arterial Stiffness In Adulthood

Objectives To investigate the relationship between fetal famine exposure and arterial stiffness in adulthood.To provide a theoretical basis for the control of arterial stiffness and cardiovascular risk factors.Methods During 2016-2019,participants born in 1956.10.1-1958.9.30,1959.10.1-1961.9.30,1962.10.1-1964.9.30 were recruited in the Kailuan study cohort for questionnaires,physical examinations,Brachial-ankle pulse wave velocity(ba PWV)measurement and laboratory biochemical tests.According to the date of birth,the included subjects were divided into fetal exposure group(1959.10.1-1961.9.30),early childhood exposure group(1956.10.1-1958.9.30)and non-famine exposure group(1962.10.1-1964.9.30).Analysis of 5524 studies in accordance with the standard,more non-famine exposure group and famine exposure group arterial stiffness sclerosis,and use Logistic regression model and linear regression model to analyze the relationship between fetal famine exposure and the detection rate of arterial stiffness in adulthood.All data were statistically analyzed using SAS9.4 software.The measurement data were expressed in (?)±S,the mean comparison among multiple groups was by one-way analysis of variance,the count data was expressed by the number and percentage(%),the comparison between groups was by the χ2 test,Multivariate logistic regression and linear regression were used to analyze the relationship between famine in fetus and arterial stiffness in adulthood.P<0.05(two-sided test)was considered statistically significant.Results In this study,5524 observation objects were included in the statistical analysis.Among them,there were 3952 males(71.54%)and 1572 females(28.46%),with an average age of 52.81±3.67 years.The detection rate of arterial stiffness in the total population was 65%,and the average ba PWV value was 1546.67 cm/s.The detection rates of arterial stiffness in fetal famine exposure group,early childhood famine exposure group,and non-famine exposure group were 67.75%,69.68%and 61.75%,respectively.Multivariate logistic regression analysis showed that compared with the nonfamine-exposed group,experiencing famine during fetal life increased the risk of developing arterial stiffness in adulthood,with an OR value of 1.40(95%CI: 1.12,1.75).After stratification by sex,salt intake,and regular physical activity,only in women(OR 1.97,95%CI: 1.30,2.99),high salt intake group(OR 1.41,95%CI: 1.10,1.80)and infrequent physical activity group(OR 1.42,95% CI: 1.11,1.80)found an association between fetal famine exposure and the development of arterial stiffness in adulthood.While men(OR=1.23,95%CI: 0.93,1.16),low-salt intake group(OR=1.31,95%CI: 0.74,2.32)and regular physical activity(OR=1.11,95%CI: 0.56),2.23)were not statistically significant.Further analysis using linear regression found similar results,with fetal famine exposure being positively correlated with ba PWV,with fetal famine exposure being 28.47 cm/s higher in ba PWV compared to the non-exposed group.After stratifying by gender,salt intake,and regular physical activity,women,high salt intake group,and infrequent physical activity group were found to be positively associated with ba PWV in fetal famine exposure.Compared with the non-famine exposure group,the ba PWV of women,high salt intake group and infrequent physical exercise group were56.99cm/s,27.78cm/s and 29.20cm/s higher in fetal famine exposure,respectively,and all were statistically significant.Conclusions Fetal famine increases the risk of developing arterial stiffnessin adulthood,mainly in females,those with high salt intake,and those with infrequent physical activity.Table14;Reference 126...