| Objectives By observing the clinical efficacy of Yiqi Huazhuo Liyan Formula(YHLF)in the treatment of post-stroke pseudobulbar paralysis dysphagia(Qi deficiency and blood stasis and turbid toxin intrinsic syndrome),to provide some reference for clinical treatment.Methods To meet the criteria of 80 cases of post-stroke pseudobulbar paralysis dysphagia,patients were randomly divided into control group and treatment group,40 cases in each group.Cases in both groups were given basic western medicine treatment of stroke + swallowing function rehabilitation training.Cases in the treatment group were treated with oral medication,YHLF.The course of treatment was 3 weeks.Before and after treatment,the Watian drinking water test score,standardized swallowing assessment(SSA)score,TCM syndrome score and swallowing disorder specific quality of life scale(SWAL-QOL)score were used to evaluate the swallowing function,quality of life and the efficacy of YHLF in the treatment of dysphagia in patients with pseudobulbar palsy after stroke.By comparing the liver and kidney function(AST,ALT,Cr),coagulation function(APTT,PT,TT)and the incidence of aspiration pneumonia in the treatment process,the safety of YHLF in the treatment of dysphagia in pseudobulbar paralysis after stroke was evaluated.At the same time,the nutritional indexes(Hb,PAB,ALB)levels and NIHSS scores of patients were compared to evaluate the nutritional status of patients and the improvement of neurological deficits.SPSS25.0 statistical software was used for data analysis and processing.Results 1 A total of 80 cases were enrolled in the trial.One case in the control group fell off,and 79 cases completed the trial(40 cases in the treatment group and 39 cases in the control group).2 There was no statistically significant difference in gender,age,grade distribution of Watian drinking water test,NIHSS score,Watian drinking water test score,SSA score,TCM syndrome score,SWAL-QOL score,nutritional index(Hb,PAB,ALB)level,liver function,renal function,and coagulation function between the two groups before treatment(P > 0.05).3 swallowing function: after 3 weeks of treatment,the scores of Watian drinking water test and SSA in the treatment group were lower than those in the control group,and the difference was statistically significant(P < 0.05).After treatment,the total effective rate of swallowing function in the treatment group(90%)was higher than that in the control group(74.3%),and the difference was statistically significant(P <0.05).4 quality of life: SWAL-QOL scores of the two groups after treatment were higher than those before treatment,and the improvement in the treatment group was stronger than that in the control group,with significant difference(P < 0.05).5 After treatment,the TCM syndrome scores of the two groups decreased compared with those before 3 weeks.The total effective rate of TCM syndrome in the treatment group(95%)was higher than that in the control group(87.2%),and the difference was statistically significant(P < 0.05).6Nutritional aspects: the treatment group after treatment nutritional indicators(Hb,PAB,ALB)decreased less than the control group,the difference was significant(P < 0.05).7Neurological deficit: NIHSS score in the treatment group was significantly lower than that in the control group after treatment,and the difference was statistically significant(P <0.05).8 Safety evaluation: There was no significant difference in liver function,renal function and coagulation function between the two cases in groups after treatment,and there was no statistical significance(P > 0.05).There was no significant difference in the incidence of aspiration pneumonia compared between the two cases in groups(P > 0.05).Conclusions 1 YHLF in the treatment of post-stroke pseudobulbar dysphagia(Qi deficiency and blood stasis and turbid toxin intrinsic syndrome)clinical curative effect is exact.The formula can significantly improve the swallowing function of patients,effectively reduce the TCM syndrome score,improve the quality of life of patients.Its curative effect is superior to that single swallowing rehabilitation training.2 YHLF can effectively improve the symptoms of neurological deficits in patients,slowing down the loss of nutrition in patients.3 YHLF showed no adverse reactions,not increasing bleeding and aspiration pneumonia infection probability,being popularized and applied in clinical.Figure 0;Table 13;Reference 139... |
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