| Objectives To observe the clinical effect of traditional Chinese medicine fumigation and washing with methylene blue partial sealing in the treatment of perianal eczema(dampheat soaked type).Methods A total of 60 patients with damp-heat soaked type perianal eczema who met the inclusion criteria from October 2020 to September 2021 in the Anorectal Department of Tangshan Traditional Chinese Medicine Hospital were collected and randomly divided into a control group and an experimental group according to the random number table method.30 cases.The control group was treated with the routine subcutaneous injection of methylene blue by partial closure,while the experimental group was treated with self-made traditional Chinese medicine fumigation and washing in addition to the basic treatment method of the control group.The general clinical data of the patients,including gender,age,and disease course,were collected,and the area of wound skin lesions,wound skin,pruritus,pigmentation,skin exudate,and sleep quality before and after treatment were recorded in the two groups of patients.The levels of serum inflammatory markers eosinophils(EOS),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR)and safety markers(liver and kidney function)were detected in the peripheral blood before and after treatment on the 14 th day.By comparing the changes in the scores of clinical observation indexes on the 1st,7th,and 14 th days before and after treatment in the two groups of patients and the changes in laboratory indexes before and after treatment,the effects of the two treatment methods on perianal eczema(damp-heat soaked type)were analyzed.The clinical efficacy difference was analyzed,and the effects of the two treatment methods on the liver and kidney function of the patients were analyzed at the same time.After 1 month,the patients in the two groups were followed up,and the recurrence rate was calculated on the basis of the total effective cases.Statistical analysis of the data was performed with SPSS 24.0 software.Results 1 Statistical analysis results showed that there was no significant difference in gender,age and course of disease between the experimental group and the control group in terms of general clinical data(P>0.05).2 On the 1st,7th and 14 th days after treatment,the itching degree and sleep quality of the experimental group were better than those of the control group,and the difference was statistically significant(P<0.05);on the 7th and 14 th days after treatment,the skin lesion area,wound leather-like changes and skin exudate improvement in the experimental group were significantly better than those in the control group,with statistical significance(P<0.05).Significantly better than the control group(P<0.05),but there was no significant difference in pigmentation between the two groups on the 14 th day after treatment(P>0.05);there was no significant difference in EOS,ESR and CRP between the experimental group and the control group before treatment.(P>0.05),comparable.After treatment,the three inflammatory indexes in the experimental group were significantly lower than those in the control group(P<0.05).During the treatment,the liver and kidney functions of the two groups were not significantly abnormal,indicating that the two treatment methods had no effect on the liver and kidney functions.There was no significant difference(P>0.05);the clinical efficacy after 14 days of treatment showed that the clinical efficacy of the experimental group was better than that of the control group,and the total effective rate of the experimental group was 90.0%,which was higher than that of the control group.76.7%,the difference was statistically significant(P<0.05).3 The two groups were followed up for 1 month after treatment,and the recurrence rate was calculated on the basis of the total effective cases.It was concluded that the recurrence rate of the experimental group was 7.41%,which was significantly lower than that of the control group,which was 34.78%,and the difference was statistically significant(P <0.05).Conclusions The self-made traditional Chinese medicine fumigation and washing formula combined with methylene blue partial sealing has a good clinical effect in the treatment of damp-heat infiltrating perianal eczema,especially in reducing the area of skin lesions,relieving the leather-like changes of the wound surface,reducing the degree of itching,improving sleep quality,reducing The curative effect of skin exudation is remarkable.According to the follow-up,it can be found that the recurrence rate is significantly reduced.Therefore,it is worthy of clinical promotion.Figure0;Table17;Reference 106... |
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